Synthesis of Tetrasubstituted Pyrazoles from Substituted Hydrazines and β-Keto Esters
1
Department of Chemistry and Biochemistry; Rowan University; 201 Mullica Hill Rd. Glassboro New Jersey USA
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Тип публикации: Journal Article
Дата публикации: 2016-10-24
scimago Q2
wos Q2
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SJR: 0.558
CiteScore: 4.3
Impact factor: 2.7
ISSN: 1434193X, 10990690
Organic Chemistry
Physical and Theoretical Chemistry
Краткое описание
Herein we report the synthesis of tetrasubstituted pyrazoles from simple hydrazines and β-keto esters under mild, basic conditions. This reaction enables the selective synthesis of pyrazolones, alkoxypyrazoles, and tetrasubstituted pyrazoles for a large variety of aromatic hydrazines and substituted β-keto esters with high yields and selectivities. This method permits access to highly complex pyrazole scaffolds with four orthogonal diversification groups.
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Bakanas I. J., Moura Letts G. Synthesis of Tetrasubstituted Pyrazoles from Substituted Hydrazines and β-Keto Esters // European Journal of Organic Chemistry. 2016. Vol. 2016. No. 32. pp. 5345-5349.
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Bakanas I. J., Moura Letts G. Synthesis of Tetrasubstituted Pyrazoles from Substituted Hydrazines and β-Keto Esters // European Journal of Organic Chemistry. 2016. Vol. 2016. No. 32. pp. 5345-5349.
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TY - JOUR
DO - 10.1002/ejoc.201601093
UR - https://doi.org/10.1002/ejoc.201601093
TI - Synthesis of Tetrasubstituted Pyrazoles from Substituted Hydrazines and β-Keto Esters
T2 - European Journal of Organic Chemistry
AU - Bakanas, Ian J
AU - Moura Letts, Gustavo
PY - 2016
DA - 2016/10/24
PB - Wiley
SP - 5345-5349
IS - 32
VL - 2016
SN - 1434-193X
SN - 1099-0690
ER -
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BibTex (до 50 авторов)
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@article{2016_Bakanas,
author = {Ian J Bakanas and Gustavo Moura Letts},
title = {Synthesis of Tetrasubstituted Pyrazoles from Substituted Hydrazines and β-Keto Esters},
journal = {European Journal of Organic Chemistry},
year = {2016},
volume = {2016},
publisher = {Wiley},
month = {oct},
url = {https://doi.org/10.1002/ejoc.201601093},
number = {32},
pages = {5345--5349},
doi = {10.1002/ejoc.201601093}
}
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MLA
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Bakanas, Ian J., and Gustavo Moura Letts. “Synthesis of Tetrasubstituted Pyrazoles from Substituted Hydrazines and β-Keto Esters.” European Journal of Organic Chemistry, vol. 2016, no. 32, Oct. 2016, pp. 5345-5349. https://doi.org/10.1002/ejoc.201601093.