Acid-Catalyzed Intramolecular Imination / Nucleophilic Trapping of 4-Aminobutanal Derivatives: One-Pot Access to 2-(Pyrazolyl)pyrrolidines
Andrey V. Smolobochkin
1, 2
,
Tanzilya S Rizbayeva
1, 2
,
Almir S. Gazizov
1, 2
,
Alexey Dobrynin
1, 4
,
Alexey B. Dobrynin
2, 5
,
Anastasiya V Gildebrant
7
,
Anna G Strelnik
1, 2
,
Ivan Sergeevich Sazykin
6
,
Ivan S Sazykin
7
,
Alexander R. Burilov
1, 2
,
Michail A. Pudovik
1, 2
,
Marina Sazykina
6
,
Marina A Sazykina
7
3
4
5
6
Publication type: Journal Article
Publication date: 2019-08-07
scimago Q2
wos Q2
SJR: 0.558
CiteScore: 4.3
Impact factor: 2.7
ISSN: 1434193X, 10990690
Organic Chemistry
Physical and Theoretical Chemistry
Abstract
A first successful synthesis of 2‐(pyrazolyl)pyrrolidines is reported starting from readily available reagents. A wide variety of N‐substituted 2‐(pyrazolyl)pyrrolidines are obtained with up to 96 % yield. The influence of the obtained compounds on biofilm formation by V. aquamarinus DSM 26054 and A. calcoaceticus VKPM B–10353 have been studied. Some of the tested compounds were found to suppress the growth of bacterial biofilms at nanomolar concentrations and thus are promising candidates for further studies.
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Total citations:
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Citations from 2024:
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(11%)
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GOST
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Smolobochkin A. V. et al. Acid-Catalyzed Intramolecular Imination / Nucleophilic Trapping of 4-Aminobutanal Derivatives: One-Pot Access to 2-(Pyrazolyl)pyrrolidines // European Journal of Organic Chemistry. 2019. Vol. 2019. No. 33. pp. 5709-5719.
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Smolobochkin A. V., Rizbayeva T. S., Gazizov A. S., Voronina J. K., Dobrynin A., Dobrynin A. B., Gildebrant A., Gildebrant A. V., Strelnik A. G., Sergeevich Sazykin I., Sazykin I. S., Burilov A. R., Pudovik M. A., Sazykina M., Sazykina M. A. Acid-Catalyzed Intramolecular Imination / Nucleophilic Trapping of 4-Aminobutanal Derivatives: One-Pot Access to 2-(Pyrazolyl)pyrrolidines // European Journal of Organic Chemistry. 2019. Vol. 2019. No. 33. pp. 5709-5719.
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TY - JOUR
DO - 10.1002/ejoc.201900868
UR - https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/ejoc.201900868
TI - Acid-Catalyzed Intramolecular Imination / Nucleophilic Trapping of 4-Aminobutanal Derivatives: One-Pot Access to 2-(Pyrazolyl)pyrrolidines
T2 - European Journal of Organic Chemistry
AU - Smolobochkin, Andrey V.
AU - Rizbayeva, Tanzilya S
AU - Gazizov, Almir S.
AU - Voronina, Julia K.
AU - Dobrynin, Alexey
AU - Dobrynin, Alexey B.
AU - Gildebrant, Anastasiya
AU - Gildebrant, Anastasiya V
AU - Strelnik, Anna G
AU - Sergeevich Sazykin, Ivan
AU - Sazykin, Ivan S
AU - Burilov, Alexander R.
AU - Pudovik, Michail A.
AU - Sazykina, Marina
AU - Sazykina, Marina A
PY - 2019
DA - 2019/08/07
PB - Wiley
SP - 5709-5719
IS - 33
VL - 2019
SN - 1434-193X
SN - 1099-0690
ER -
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@article{2019_Smolobochkin,
author = {Andrey V. Smolobochkin and Tanzilya S Rizbayeva and Almir S. Gazizov and Julia K. Voronina and Alexey Dobrynin and Alexey B. Dobrynin and Anastasiya Gildebrant and Anastasiya V Gildebrant and Anna G Strelnik and Ivan Sergeevich Sazykin and Ivan S Sazykin and Alexander R. Burilov and Michail A. Pudovik and Marina Sazykina and Marina A Sazykina},
title = {Acid-Catalyzed Intramolecular Imination / Nucleophilic Trapping of 4-Aminobutanal Derivatives: One-Pot Access to 2-(Pyrazolyl)pyrrolidines},
journal = {European Journal of Organic Chemistry},
year = {2019},
volume = {2019},
publisher = {Wiley},
month = {aug},
url = {https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/ejoc.201900868},
number = {33},
pages = {5709--5719},
doi = {10.1002/ejoc.201900868}
}
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MLA
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Smolobochkin, Andrey V., et al. “Acid-Catalyzed Intramolecular Imination / Nucleophilic Trapping of 4-Aminobutanal Derivatives: One-Pot Access to 2-(Pyrazolyl)pyrrolidines.” European Journal of Organic Chemistry, vol. 2019, no. 33, Aug. 2019, pp. 5709-5719. https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/ejoc.201900868.