C‐H Activation of 2‐Arylbenzoxazinones in Aqueous Medium: Synthesis of Fused Isoindolinones Using a Heterogeneous Magnetic Pd‐Catalyst

We have developed a C-H activation protocol of 2-arylbenzoxazinones in aqueous medium under open aerial atmosphere at close to room temperature (40 oC) using magnetic Pd-catalyst. 2-Arylbenzoxazinones react with phenylglyoxylic acids via decarboxylative C-H acylation followed by cyclization reaction to produce the isoindolinone compounds. The reaction can be arrested at the intermediate step to obtain the ortho-acylated derivative at a certain lower temperature. The heterogeneous Pd-catalyst is easy to separate magnetically and shows good recyclability.