Electrophoresis, volume 35, issue 9, pages 1285-1307

Metabolomic investigation of human diseases biomarkers by CE and LC coupled to MS

Adriana Z Buzatto ¹

Ana Carolina De Sousa ¹

Sumaya F Guedes ¹

Zuzana Cieslarova ¹

Ana Valéria Colnaghi Simionato ^{1, 2}

Hide authors affiliations Show authors affiliations: 2 affiliations

Institute of Chemistry; University of Campinas - Unicamp; Campinas Brazil |

National Institute of Science and Technology in Bioanalytics; Campinas Brazil |

Publication type: Journal Article

Publication date: 2014-02-14

Wiley

Journal: Electrophoresis

Quartile SCImago

Quartile WOS

Impact factor: 2.9

ISSN: 01730835, 15222683

DOI: 10.1002/elps.201300470

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Biochemistry

Clinical Biochemistry

Analytical Chemistry

Abstract

Metabolomics is one of the most recent trends in the "omics" era that investigates the end products of an organism activity, that is, all metabolites in a biological system, which are small molecules (less than 1000 Da) from different chemical classes. Metabolomics represents a tool to assess the biochemical activity of a living system through the analysis of substrates and products processed during the metabolism. The analysis of the metabolic profile (nontargeted analysis, i.e. a comparison between samples profiles of individuals) and of specific metabolites (targeted analysis, which quantifies a selected group of metabolites) in biological samples provides an insight into the metabolic state and the biochemical processes of the organism and, therefore, may indicate the onset and the stage of different diseases. An early and accurate diagnosis is essential for successful treatment and probable cure of most illnesses; hence, the investigation of metabolites as disease biomarkers has increased considerably in recent years. This review aims to present the most relevant works that address the nontargeted and targeted analysis of metabolites in different diseases for the past 10 years, including kidney and neurological disorders, cardiovascular diseases, diabetes, and cancer, using CE and LC coupled with the accurate detection of mass spectroscopy.

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Citations by journals

	1 2
Journal of Pharmaceutical and Biomedical Analysis	Journal of Pharmaceutical and Biomedical Analysis, 2, 10% Journal of Pharmaceutical and Biomedical Analysis 2 publications, 10%
Advances in Experimental Medicine and Biology	Advances in Experimental Medicine and Biology, 2, 10% Advances in Experimental Medicine and Biology 2 publications, 10%
American Journal of Chinese Medicine	American Journal of Chinese Medicine, 1, 5% American Journal of Chinese Medicine 1 publication, 5%
Cancers	Cancers, 1, 5% Cancers 1 publication, 5%
Frontiers in Endocrinology	Frontiers in Endocrinology, 1, 5% Frontiers in Endocrinology 1 publication, 5%
Frontiers in Neurology	Frontiers in Neurology, 1, 5% Frontiers in Neurology 1 publication, 5%
Trials	Trials, 1, 5% Trials 1 publication, 5%
Analytical and Bioanalytical Chemistry	Analytical and Bioanalytical Chemistry, 1, 5% Analytical and Bioanalytical Chemistry 1 publication, 5%
Metabolomics	Metabolomics, 1, 5% Metabolomics 1 publication, 5%
Drug Discovery Today: Technologies	Drug Discovery Today: Technologies, 1, 5% Drug Discovery Today: Technologies 1 publication, 5%
Advances in Medical Sciences	Advances in Medical Sciences, 1, 5% Advances in Medical Sciences 1 publication, 5%
Microchemical Journal	Microchemical Journal, 1, 5% Microchemical Journal 1 publication, 5%
Journal of Critical Care	Journal of Critical Care, 1, 5% Journal of Critical Care 1 publication, 5%
Electrophoresis	Electrophoresis, 1, 5% Electrophoresis 1 publication, 5%
Environmental Entomology	Environmental Entomology, 1, 5% Environmental Entomology 1 publication, 5%
Advances in Imaging and Electron Physics	Advances in Imaging and Electron Physics, 1, 5% Advances in Imaging and Electron Physics 1 publication, 5%
Journal of Traditional Chinese Medical Sciences	Journal of Traditional Chinese Medical Sciences, 1, 5% Journal of Traditional Chinese Medical Sciences 1 publication, 5%
Russian Chemical Reviews	Russian Chemical Reviews, 1, 5% Russian Chemical Reviews 1 publication, 5%
	1 2

Citations by publishers

	1 2 3 4 5 6 7
Elsevier	Elsevier, 7, 35% Elsevier 7 publications, 35%
Springer Nature	Springer Nature, 5, 25% Springer Nature 5 publications, 25%
Frontiers Media S.A.	Frontiers Media S.A., 2, 10% Frontiers Media S.A. 2 publications, 10%
World Scientific	World Scientific, 1, 5% World Scientific 1 publication, 5%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 1, 5% Multidisciplinary Digital Publishing Institute (MDPI) 1 publication, 5%
Wiley	Wiley, 1, 5% Wiley 1 publication, 5%
Entomological Society of America	Entomological Society of America, 1, 5% Entomological Society of America 1 publication, 5%
Beijing University of Chinese Medicine	Beijing University of Chinese Medicine, 1, 5% Beijing University of Chinese Medicine 1 publication, 5%
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii	Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii, 1, 5% Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii 1 publication, 5%
	1 2 3 4 5 6 7

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Buzatto A. Z. et al. Metabolomic investigation of human diseases biomarkers by CE and LC coupled to MS // Electrophoresis. 2014. Vol. 35. No. 9. pp. 1285-1307.

GOST all authors (up to 50) Copy

Buzatto A. Z., De Sousa A. C., Guedes S. F., Cieslarova Z., Simionato A. V. C. Metabolomic investigation of human diseases biomarkers by CE and LC coupled to MS // Electrophoresis. 2014. Vol. 35. No. 9. pp. 1285-1307.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1002/elps.201300470

UR - https://doi.org/10.1002/elps.201300470

TI - Metabolomic investigation of human diseases biomarkers by CE and LC coupled to MS

T2 - Electrophoresis

AU - Buzatto, Adriana Z

AU - De Sousa, Ana Carolina

AU - Guedes, Sumaya F

AU - Cieslarova, Zuzana

AU - Simionato, Ana Valéria Colnaghi

PY - 2014

DA - 2014/02/14 00:00:00

PB - Wiley

SP - 1285-1307

IS - 9

VL - 35

SN - 0173-0835

SN - 1522-2683

ER -

BibTex |

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BibTex Copy

@article{2014_Buzatto,

author = {Adriana Z Buzatto and Ana Carolina De Sousa and Sumaya F Guedes and Zuzana Cieslarova and Ana Valéria Colnaghi Simionato},

title = {Metabolomic investigation of human diseases biomarkers by CE and LC coupled to MS},

journal = {Electrophoresis},

year = {2014},

volume = {35},

publisher = {Wiley},

month = {feb},

url = {https://doi.org/10.1002/elps.201300470},

number = {9},

pages = {1285--1307},

doi = {10.1002/elps.201300470}

}

MLA

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Buzatto, Adriana Z., et al. “Metabolomic investigation of human diseases biomarkers by CE and LC coupled to MS.” Electrophoresis, vol. 35, no. 9, Feb. 2014, pp. 1285-1307. https://doi.org/10.1002/elps.201300470.

Found error?

Publisher

Wiley

Journal

Electrophoresis

Quartile SCImago

Quartile WOS

Impact factor

2.9

ISSN

01730835 (Print)
15222683 (Electronic)