Electrophoresis, volume 35, issue 9, pages 1285-1307
Metabolomic investigation of human diseases biomarkers by CE and LC coupled to MS
Adriana Z Buzatto
1
,
Ana Carolina De Sousa
1
,
Sumaya F Guedes
1
,
Zuzana Cieslarova
1
,
Ana Valéria Colnaghi Simionato
1, 2
2
National Institute of Science and Technology in Bioanalytics; Campinas Brazil
|
Publication type: Journal Article
Publication date: 2014-02-14
Biochemistry
Clinical Biochemistry
Analytical Chemistry
Abstract
Metabolomics is one of the most recent trends in the "omics" era that investigates the end products of an organism activity, that is, all metabolites in a biological system, which are small molecules (less than 1000 Da) from different chemical classes. Metabolomics represents a tool to assess the biochemical activity of a living system through the analysis of substrates and products processed during the metabolism. The analysis of the metabolic profile (nontargeted analysis, i.e. a comparison between samples profiles of individuals) and of specific metabolites (targeted analysis, which quantifies a selected group of metabolites) in biological samples provides an insight into the metabolic state and the biochemical processes of the organism and, therefore, may indicate the onset and the stage of different diseases. An early and accurate diagnosis is essential for successful treatment and probable cure of most illnesses; hence, the investigation of metabolites as disease biomarkers has increased considerably in recent years. This review aims to present the most relevant works that address the nontargeted and targeted analysis of metabolites in different diseases for the past 10 years, including kidney and neurological disorders, cardiovascular diseases, diabetes, and cancer, using CE and LC coupled with the accurate detection of mass spectroscopy.
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Buzatto A. Z. et al. Metabolomic investigation of human diseases biomarkers by CE and LC coupled to MS // Electrophoresis. 2014. Vol. 35. No. 9. pp. 1285-1307.
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Buzatto A. Z., De Sousa A. C., Guedes S. F., Cieslarova Z., Simionato A. V. C. Metabolomic investigation of human diseases biomarkers by CE and LC coupled to MS // Electrophoresis. 2014. Vol. 35. No. 9. pp. 1285-1307.
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TY - JOUR
DO - 10.1002/elps.201300470
UR - https://doi.org/10.1002/elps.201300470
TI - Metabolomic investigation of human diseases biomarkers by CE and LC coupled to MS
T2 - Electrophoresis
AU - Buzatto, Adriana Z
AU - De Sousa, Ana Carolina
AU - Guedes, Sumaya F
AU - Cieslarova, Zuzana
AU - Simionato, Ana Valéria Colnaghi
PY - 2014
DA - 2014/02/14
PB - Wiley
SP - 1285-1307
IS - 9
VL - 35
SN - 0173-0835
SN - 1522-2683
ER -
Cite this
BibTex (up to 50 authors)
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@article{2014_Buzatto,
author = {Adriana Z Buzatto and Ana Carolina De Sousa and Sumaya F Guedes and Zuzana Cieslarova and Ana Valéria Colnaghi Simionato},
title = {Metabolomic investigation of human diseases biomarkers by CE and LC coupled to MS},
journal = {Electrophoresis},
year = {2014},
volume = {35},
publisher = {Wiley},
month = {feb},
url = {https://doi.org/10.1002/elps.201300470},
number = {9},
pages = {1285--1307},
doi = {10.1002/elps.201300470}
}
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MLA
Copy
Buzatto, Adriana Z., et al. “Metabolomic investigation of human diseases biomarkers by CE and LC coupled to MS.” Electrophoresis, vol. 35, no. 9, Feb. 2014, pp. 1285-1307. https://doi.org/10.1002/elps.201300470.