Electrophoresis
Combining amperometry and mass spectrometry as a dual detection approach for capillary electrophoresis
Publication type: Journal Article
Publication date: 2022-11-22
Journal:
Electrophoresis
Quartile SCImago
Q2
Quartile WOS
Q2
Impact factor: 2.9
ISSN: 01730835, 15222683
Biochemistry
Clinical Biochemistry
Analytical Chemistry
Abstract
Dual detection concepts (DDCs) are becoming more and more popular in analytical chemistry. In this work, we describe a novel DDC for capillary electrophoresis (CE) consisting of an amperometric detector (AD) and a mass spectrometer (MS). This detector combination has a good complementarity as the AD exhibits high sensitivity, whereas the MS provides excellent selectivity. Both detectors are based on a destructive detection principle, making a serial detector arrangement impossible. Thus, for the realization of the DDC, the CE flow was divided into two parts with a flow splitter. The DDC was characterized in a proof-of-concept study with ferrocene derivates and a nonaqueous background electrolyte. We could show that splitting the CE flow was a suitable method for the instrumental realization of the DDC consisting of two destructive detectors. By lowering the height of the AD compared to the MS, it was possible to synchronize the detector responses. Additionally, for the chosen model system, we confirmed that the AD was much more reproducible and had lower limits of detection (LODs) than the MS. The LODs were identical for the DDC and the single-detection arrangements, indicating no sensitivity decrease due to the CE flow splitting. The DDC was successfully applied to determine the drug and doping agent trimetazidine.
Top-30
Citations by journals
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1
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Monatshefte fur Chemie
1 publication, 12.5%
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Electrophoresis
1 publication, 12.5%
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Electroanalysis
1 publication, 12.5%
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Sensors
1 publication, 12.5%
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Journal of Chromatography A
1 publication, 12.5%
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Analytical Chemistry
1 publication, 12.5%
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Russian Chemical Reviews
1 publication, 12.5%
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1
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Citations by publishers
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1
2
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Wiley
2 publications, 25%
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Springer Nature
1 publication, 12.5%
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Multidisciplinary Digital Publishing Institute (MDPI)
1 publication, 12.5%
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Elsevier
1 publication, 12.5%
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American Chemical Society (ACS)
1 publication, 12.5%
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Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 publication, 12.5%
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- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Böhm D., Koall M., Matysik F. Combining amperometry and mass spectrometry as a dual detection approach for capillary electrophoresis // Electrophoresis. 2022.
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Böhm D., Koall M., Matysik F. Combining amperometry and mass spectrometry as a dual detection approach for capillary electrophoresis // Electrophoresis. 2022.
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TY - JOUR
DO - 10.1002/elps.202200228
UR - https://doi.org/10.1002/elps.202200228
TI - Combining amperometry and mass spectrometry as a dual detection approach for capillary electrophoresis
T2 - Electrophoresis
AU - Böhm, Daniel
AU - Koall, Martin
AU - Matysik, Frank-Michael
PY - 2022
DA - 2022/11/22 00:00:00
PB - Wiley
SN - 0173-0835
SN - 1522-2683
ER -
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@article{2022_Böhm,
author = {Daniel Böhm and Martin Koall and Frank-Michael Matysik},
title = {Combining amperometry and mass spectrometry as a dual detection approach for capillary electrophoresis},
journal = {Electrophoresis},
year = {2022},
publisher = {Wiley},
month = {nov},
url = {https://doi.org/10.1002/elps.202200228},
doi = {10.1002/elps.202200228}
}