Journal of Heterocyclic Chemistry, volume 59, issue 8, pages 1366-1375
Design, synthesis, insecticidal activities, and molecular docking of novel pyridylpyrazolo carboxylate derivatives
Publication type: Journal Article
Publication date: 2022-03-21
Journal:
Journal of Heterocyclic Chemistry
Quartile SCImago
Q3
Quartile WOS
Q2
Impact factor: 2.4
ISSN: 0022152X, 19435193
Organic Chemistry
Abstract
Based on our previous work, using the strategies of “scaffold hopping” and “intermediate derivatization method” (IDM), a total of 44 novel pyridylpyrazolo carboxylate derivatives were designed and synthesized. The structures of these compounds were identified by 1H NMR and 13C NMR, and the insecticidal activities of the target compounds against Plutella xylostella and Spodoptera frugiperda were tested. Compound G35 showed the best insecticidal activities against P. xylostella (LC50 = 33.65 mg/L) and S. frugiperda (mortality rate = 61.21% at 100 mg/L). Preliminary structure–activity relationship analysis showed that the introduction of amino group and acetamide on the benzene ring helped to improve the insecticidal activity of the scaffold. Molecular docking model between compounds G34 or G35 and Ryanodine receptors (RyRs) of P. xylostella showed that RyRs may be a potential target of this series compounds and explained the difference in insecticidal activities. These findings provided guidance for further optimization of the pyridylpyrazolo carboxylate scaffold as potential insecticide.
Top-30
Citations by journals
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Frontiers in Chemistry
1 publication, 20%
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Toxics
1 publication, 20%
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Chemosphere
1 publication, 20%
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Russian Chemical Reviews
1 publication, 20%
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Heliyon
1 publication, 20%
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Citations by publishers
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2
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Elsevier
2 publications, 40%
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Frontiers Media S.A.
1 publication, 20%
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Multidisciplinary Digital Publishing Institute (MDPI)
1 publication, 20%
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Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 publication, 20%
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- We do not take into account publications without a DOI.
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Yang S. et al. Design, synthesis, insecticidal activities, and molecular docking of novel pyridylpyrazolo carboxylate derivatives // Journal of Heterocyclic Chemistry. 2022. Vol. 59. No. 8. pp. 1366-1375.
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Yang S., Peng H., Zhu J., Chen Z., Xu H. Design, synthesis, insecticidal activities, and molecular docking of novel pyridylpyrazolo carboxylate derivatives // Journal of Heterocyclic Chemistry. 2022. Vol. 59. No. 8. pp. 1366-1375.
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TY - JOUR
DO - 10.1002/jhet.4476
UR - https://doi.org/10.1002/jhet.4476
TI - Design, synthesis, insecticidal activities, and molecular docking of novel pyridylpyrazolo carboxylate derivatives
T2 - Journal of Heterocyclic Chemistry
AU - Peng, Hongxiang
AU - Zhu, Jinyi
AU - Xu, Hanhong
AU - Yang, Shuai
AU - Chen, Zhao
PY - 2022
DA - 2022/03/21 00:00:00
PB - Wiley
SP - 1366-1375
IS - 8
VL - 59
SN - 0022-152X
SN - 1943-5193
ER -
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@article{2022_Yang,
author = {Hongxiang Peng and Jinyi Zhu and Hanhong Xu and Shuai Yang and Zhao Chen},
title = {Design, synthesis, insecticidal activities, and molecular docking of novel pyridylpyrazolo carboxylate derivatives},
journal = {Journal of Heterocyclic Chemistry},
year = {2022},
volume = {59},
publisher = {Wiley},
month = {mar},
url = {https://doi.org/10.1002/jhet.4476},
number = {8},
pages = {1366--1375},
doi = {10.1002/jhet.4476}
}
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Yang, Shuai, et al. “Design, synthesis, insecticidal activities, and molecular docking of novel pyridylpyrazolo carboxylate derivatives.” Journal of Heterocyclic Chemistry, vol. 59, no. 8, Mar. 2022, pp. 1366-1375. https://doi.org/10.1002/jhet.4476.