Hantaan virus infection in suckling mice: Virologic and pathologic correlates
1
U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland
|
2
U. S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland
|
Publication type: Journal Article
Publication date: 1985-10-01
scimago Q1
wos Q1
SJR: 1.291
CiteScore: 12.7
Impact factor: 4.6
ISSN: 01466615, 10969071
PubMed ID:
2865331
Infectious Diseases
Virology
Abstract
The Hantaan virus suckling mouse model was examined to delineate virologic and histopathologic characteristics of infection at the organ level. Viral antigen and infectious virus were detected in all organs examined, with highest titers achieved in brain, lung, and kidney. A constellation of histologic lesions was identified in brain (diffuse meningoencephalitis with bilaterally symmetrical thalamic necrosis), liver (pericholangiohepatitis), lung (pneumonitis), and spleen (lymphoid hyperplasia); this tetrad is apparently unique to this model system. The chronology of clinical, virologic, serologic, and pathologic findings in Hantaan-infected newborn mice suggests an immune-mediated mechanism in disease pathogenesis.
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Total citations:
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Citations from 2024:
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(6.26%)
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GOST
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MCKEE K. T. et al. Hantaan virus infection in suckling mice: Virologic and pathologic correlates // Journal of Medical Virology. 1985. Vol. 17. No. 2. pp. 107-117.
GOST all authors (up to 50)
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MCKEE K. T., Kim G. R., Green D. E., Peters C. J. Hantaan virus infection in suckling mice: Virologic and pathologic correlates // Journal of Medical Virology. 1985. Vol. 17. No. 2. pp. 107-117.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1002/jmv.1890170203
UR - https://doi.org/10.1002/jmv.1890170203
TI - Hantaan virus infection in suckling mice: Virologic and pathologic correlates
T2 - Journal of Medical Virology
AU - MCKEE, KELLY T.
AU - Kim, Gum Ryong
AU - Green, David E.
AU - Peters, C. J.
PY - 1985
DA - 1985/10/01
PB - Wiley
SP - 107-117
IS - 2
VL - 17
PMID - 2865331
SN - 0146-6615
SN - 1096-9071
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{1985_MCKEE,
author = {KELLY T. MCKEE and Gum Ryong Kim and David E. Green and C. J. Peters},
title = {Hantaan virus infection in suckling mice: Virologic and pathologic correlates},
journal = {Journal of Medical Virology},
year = {1985},
volume = {17},
publisher = {Wiley},
month = {oct},
url = {https://doi.org/10.1002/jmv.1890170203},
number = {2},
pages = {107--117},
doi = {10.1002/jmv.1890170203}
}
Cite this
MLA
Copy
MCKEE, KELLY T., et al. “Hantaan virus infection in suckling mice: Virologic and pathologic correlates.” Journal of Medical Virology, vol. 17, no. 2, Oct. 1985, pp. 107-117. https://doi.org/10.1002/jmv.1890170203.