Synthesis, hydrolytic behavior, and anti-HIV activity of selected acyloxyalkyl esters of trisodium phosphonoformate (foscarnet sodium).
Publication type: Journal Article
Publication date: 1994-09-01
scimago Q1
wos Q2
SJR: 0.737
CiteScore: 7.2
Impact factor: 3.8
ISSN: 00223549, 15206017
PubMed ID:
7530302
Pharmaceutical Science
Abstract
The synthesis and anti-HIV activity of selected (acyloxy)alkyl esters of trisodium phosphonoformate (foscarnet sodium) are described. The conversion of bis(trimethylsilyl) (alkoxycarbonyl)phosphonates 11a-d to the corresponding disilver salts 12a-d and their subsequent reaction with iodoalkyl acrylates 4a-c gave the desired bis(acyloxyalkyl) phosphonates 6-9(a-c). Of the analogs tested, only the dichlorophenyl analog 9a showed a dose-dependent inhibition of HIV activity in H9 cells. Using 31P-NMR, bioreversibility has been investigated in an attempt to rationalize these results.
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13
Total citations:
13
Citations from 2025:
1
(7.69%)
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MLA
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GOST
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Iyer R. P. et al. Synthesis, hydrolytic behavior, and anti-HIV activity of selected acyloxyalkyl esters of trisodium phosphonoformate (foscarnet sodium). // Journal of Pharmaceutical Sciences. 1994. Vol. 83. No. 9. pp. 1269-1273.
GOST all authors (up to 50)
Copy
Iyer R. P., Phillips L. R., Phillips L. H., Thakker D. R., EGAN W. Synthesis, hydrolytic behavior, and anti-HIV activity of selected acyloxyalkyl esters of trisodium phosphonoformate (foscarnet sodium). // Journal of Pharmaceutical Sciences. 1994. Vol. 83. No. 9. pp. 1269-1273.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1002/jps.2600830916
UR - https://doi.org/10.1002/jps.2600830916
TI - Synthesis, hydrolytic behavior, and anti-HIV activity of selected acyloxyalkyl esters of trisodium phosphonoformate (foscarnet sodium).
T2 - Journal of Pharmaceutical Sciences
AU - Iyer, Radhakrishnan P
AU - Phillips, Lawrence R
AU - Phillips, Lawrence H.
AU - Thakker, Dhiren R.
AU - EGAN, WILLIAM
PY - 1994
DA - 1994/09/01
PB - Elsevier
SP - 1269-1273
IS - 9
VL - 83
PMID - 7530302
SN - 0022-3549
SN - 1520-6017
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{1994_Iyer,
author = {Radhakrishnan P Iyer and Lawrence R Phillips and Lawrence H. Phillips and Dhiren R. Thakker and WILLIAM EGAN},
title = {Synthesis, hydrolytic behavior, and anti-HIV activity of selected acyloxyalkyl esters of trisodium phosphonoformate (foscarnet sodium).},
journal = {Journal of Pharmaceutical Sciences},
year = {1994},
volume = {83},
publisher = {Elsevier},
month = {sep},
url = {https://doi.org/10.1002/jps.2600830916},
number = {9},
pages = {1269--1273},
doi = {10.1002/jps.2600830916}
}
Cite this
MLA
Copy
Iyer, Radhakrishnan P., et al. “Synthesis, hydrolytic behavior, and anti-HIV activity of selected acyloxyalkyl esters of trisodium phosphonoformate (foscarnet sodium)..” Journal of Pharmaceutical Sciences, vol. 83, no. 9, Sep. 1994, pp. 1269-1273. https://doi.org/10.1002/jps.2600830916.