Both heat and new chemotherapeutic drug dioxadet in hyperthermic intraperitoneal chemoperfusion improved survival in rat ovarian cancer model
Vladimir Bespalov
1, 2
,
Galina Kireeva
1, 2
,
Olesya A Belyaeva
1, 2
,
Oleksiy E Kalinin
3
,
Konstantin Y Senchik
1
,
Alexandr N Stukov
1
,
Georgy I Gafton
1
,
Konstantin D Guseynov
1
,
Alexey M. Belyaev
1
3
Lugansk Oncological Dispensary, Lugansk, Ukraine; 8, Krasnodonskaya Street; Lugansk Ukraine
|
Publication type: Journal Article
Publication date: 2015-12-29
scimago Q1
wos Q2
SJR: 0.741
CiteScore: 4.2
Impact factor: 1.9
ISSN: 00224790, 10969098, 26743000
PubMed ID:
26710749
Oncology
General Medicine
Surgery
Abstract
Hyperthermic Intraperitoneal Chemotherapy (HIPEC) at the time of Cytoreductive Surgery (CRS) is an actively researched treatment in patients with advanced ovarian cancer. Relative contribution of heat and chemotherapeutic agents during HIPEC as well as efficacy of a new agent dioxadet for regional chemotherapy in a rat model of ovarian cancer was studied.Sixty rats were divided into three groups: no treatment control group (n = 19), hyperthermia without chemotherapy (HIPEP) (n = 14), HIPEC + cisplatin (n = 14), HIPEC + dioxadet (n = 13). The intra-abdominal tumor was not resected. End points were: median survival (primary), cause of death (secondary).The median survival of the animals in the control group, HIPEP group, HIPEC + cisplatin, HIPEC + dioxadet were 9 (CI; 8-23), 22.5 (CI; 12-43), 25.5 (CI; 13-62), 49 (Cl; 28-70) days, respectively. The P-values control versus HIPEP, HIPEC + cisplatin versus HIPEC + dioxadet were 0.006, 0.002, and 0.001, respectively.During HIPEC both the heat and the cytotoxic drug had antitumor effects in a rat ovarian cancer model. Dioxadet showed potential as a drug for regional chemotherapy. J. Surg. Oncol. 2016;113:438-442. © 2015 Wiley Periodicals, Inc.
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Bespalov V. et al. Both heat and new chemotherapeutic drug dioxadet in hyperthermic intraperitoneal chemoperfusion improved survival in rat ovarian cancer model // Journal of Surgical Oncology. 2015. Vol. 113. No. 4. pp. 438-442.
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Bespalov V., Kireeva G., Belyaeva O. A., Kalinin O. E., Senchik K. Y., Stukov A. N., Gafton G. I., Guseynov K. D., Belyaev A. M. Both heat and new chemotherapeutic drug dioxadet in hyperthermic intraperitoneal chemoperfusion improved survival in rat ovarian cancer model // Journal of Surgical Oncology. 2015. Vol. 113. No. 4. pp. 438-442.
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RIS
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TY - JOUR
DO - 10.1002/jso.24140
UR - https://doi.org/10.1002/jso.24140
TI - Both heat and new chemotherapeutic drug dioxadet in hyperthermic intraperitoneal chemoperfusion improved survival in rat ovarian cancer model
T2 - Journal of Surgical Oncology
AU - Bespalov, Vladimir
AU - Kireeva, Galina
AU - Belyaeva, Olesya A
AU - Kalinin, Oleksiy E
AU - Senchik, Konstantin Y
AU - Stukov, Alexandr N
AU - Gafton, Georgy I
AU - Guseynov, Konstantin D
AU - Belyaev, Alexey M.
PY - 2015
DA - 2015/12/29
PB - Wiley
SP - 438-442
IS - 4
VL - 113
PMID - 26710749
SN - 0022-4790
SN - 1096-9098
SN - 2674-3000
ER -
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BibTex (up to 50 authors)
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@article{2015_Bespalov,
author = {Vladimir Bespalov and Galina Kireeva and Olesya A Belyaeva and Oleksiy E Kalinin and Konstantin Y Senchik and Alexandr N Stukov and Georgy I Gafton and Konstantin D Guseynov and Alexey M. Belyaev},
title = {Both heat and new chemotherapeutic drug dioxadet in hyperthermic intraperitoneal chemoperfusion improved survival in rat ovarian cancer model},
journal = {Journal of Surgical Oncology},
year = {2015},
volume = {113},
publisher = {Wiley},
month = {dec},
url = {https://doi.org/10.1002/jso.24140},
number = {4},
pages = {438--442},
doi = {10.1002/jso.24140}
}
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MLA
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Bespalov, Vladimir, et al. “Both heat and new chemotherapeutic drug dioxadet in hyperthermic intraperitoneal chemoperfusion improved survival in rat ovarian cancer model.” Journal of Surgical Oncology, vol. 113, no. 4, Dec. 2015, pp. 438-442. https://doi.org/10.1002/jso.24140.