Journal of Separation Science, volume 40, issue 17, pages 3487-3496
Evaluation of microextraction by packed sorbent, liquid-liquid microextraction and derivatization pretreatment of diet-derived phenolic acids in plasma by gas chromatography with triple quadrupole mass spectrometry
Luis Bustamante
1
,
Diana Cárdenas
1
,
Dietrich von Baer
1
,
Edgar Pastene
2
,
Daniel Duran-Sandoval
3
,
Carola Vergara
1
,
1
Department of Instrumental Analysis, Faculty of Pharmacy; Universidad de Concepción; Concepción Chile
|
2
Department of Pharmacy, Faculty of Pharmacy; Universidad de Concepción; Concepción Chile
|
3
Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy; Universidad de Concepción; Concepción Chile
|
Publication type: Journal Article
Publication date: 2017-07-31
Journal:
Journal of Separation Science
Quartile SCImago
Q2
Quartile WOS
Q2
Impact factor: 3.1
ISSN: 16159306, 16159314
Analytical Chemistry
Filtration and Separation
Abstract
Miniaturized sample pretreatments for the analysis of phenolic metabolites in plasma, involving protein precipitation, enzymatic deconjugation, extraction procedures, and different derivatization reactions were systematically evaluated. The analyses were conducted by gas chromatography with mass spectrometry for the evaluation of 40 diet-derived phenolic compounds. Enzyme purification was necessary for the phenolic deconjugation before extraction. Trimethylsilanization reagent and two different tetrabutylammonium salts for derivatization reactions were compared. The optimum reaction conditions were 50 μL of trimethylsilanization reagent at 90°C for 30 min, while tetrabutylammonium salts were associated with loss of sensitivity due to rapid activation of the inert gas chromatograph liner. Phenolic acids extractions from plasma were optimized. Optimal microextraction by packed sorbent performance was achieved using an octadecylsilyl packed bed and better recoveries for less polar compounds, such as methoxylated derivatives, were observed. Despite the low recovery for many analytes, repeatability using an automated extraction procedure in the gas chromatograph inlet was 2.5%. Instead, using liquid-liquid microextraction, better recoveries (80-110%) for all analytes were observed at the expense of repeatability (3.8-18.4%). The phenolic compounds in gerbil plasma samples, collected before and 4 h after the administration of a calafate extract, were analyzed with the optimized methodology.
Top-30
Citations by journals
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2 publications, 18.18%
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1 publication, 9.09%
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Chinese Journal of Chromatography (Se Pu)
1 publication, 9.09%
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Journal of Chromatography A
1 publication, 9.09%
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1 publication, 9.09%
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Journal of Pharmaceutical and Biomedical Analysis
1 publication, 9.09%
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The Analyst
1 publication, 9.09%
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1 publication, 9.09%
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TrAC - Trends in Analytical Chemistry
1 publication, 9.09%
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Russian Chemical Reviews
1 publication, 9.09%
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1
2
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Citations by publishers
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1
2
3
4
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Elsevier
4 publications, 36.36%
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Wiley
2 publications, 18.18%
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Multidisciplinary Digital Publishing Institute (MDPI)
1 publication, 9.09%
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Zhongguo Kexueyan Ganguang Huaxue Yanjiusuo
1 publication, 9.09%
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Royal Society of Chemistry (RSC)
1 publication, 9.09%
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Turkish Chemical Society
1 publication, 9.09%
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Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 publication, 9.09%
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1
2
3
4
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- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Bustamante L. et al. Evaluation of microextraction by packed sorbent, liquid-liquid microextraction and derivatization pretreatment of diet-derived phenolic acids in plasma by gas chromatography with triple quadrupole mass spectrometry // Journal of Separation Science. 2017. Vol. 40. No. 17. pp. 3487-3496.
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Bustamante L., Cárdenas D., von Baer D., Pastene E., Duran-Sandoval D., Vergara C., Mardones C. Evaluation of microextraction by packed sorbent, liquid-liquid microextraction and derivatization pretreatment of diet-derived phenolic acids in plasma by gas chromatography with triple quadrupole mass spectrometry // Journal of Separation Science. 2017. Vol. 40. No. 17. pp. 3487-3496.
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TY - JOUR
DO - 10.1002/jssc.201700343
UR - https://doi.org/10.1002/jssc.201700343
TI - Evaluation of microextraction by packed sorbent, liquid-liquid microextraction and derivatization pretreatment of diet-derived phenolic acids in plasma by gas chromatography with triple quadrupole mass spectrometry
T2 - Journal of Separation Science
AU - Cárdenas, Diana
AU - von Baer, Dietrich
AU - Duran-Sandoval, Daniel
AU - Vergara, Carola
AU - Mardones, Claudia
AU - Bustamante, Luis
AU - Pastene, Edgar
PY - 2017
DA - 2017/07/31 00:00:00
PB - Wiley
SP - 3487-3496
IS - 17
VL - 40
SN - 1615-9306
SN - 1615-9314
ER -
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@article{2017_Bustamante,
author = {Diana Cárdenas and Dietrich von Baer and Daniel Duran-Sandoval and Carola Vergara and Claudia Mardones and Luis Bustamante and Edgar Pastene},
title = {Evaluation of microextraction by packed sorbent, liquid-liquid microextraction and derivatization pretreatment of diet-derived phenolic acids in plasma by gas chromatography with triple quadrupole mass spectrometry},
journal = {Journal of Separation Science},
year = {2017},
volume = {40},
publisher = {Wiley},
month = {jul},
url = {https://doi.org/10.1002/jssc.201700343},
number = {17},
pages = {3487--3496},
doi = {10.1002/jssc.201700343}
}
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Bustamante, Luis, et al. “Evaluation of microextraction by packed sorbent, liquid-liquid microextraction and derivatization pretreatment of diet-derived phenolic acids in plasma by gas chromatography with triple quadrupole mass spectrometry.” Journal of Separation Science, vol. 40, no. 17, Jul. 2017, pp. 3487-3496. https://doi.org/10.1002/jssc.201700343.