Journal of Separation Science, publication number jssc.201900258
Trace enrichment of phenylcarboxylic acids from a model biological fluid and serum of human blood
Publication type: Journal Article
Publication date: 2019-06-08
Journal:
Journal of Separation Science
Quartile SCImago
Q2
Quartile WOS
Q2
Impact factor: 3.1
ISSN: 16159306, 16159314
Analytical Chemistry
Filtration and Separation
Abstract
The study was focused on the development of a solid-phase extraction protocol for seven phenylcarboxylic acids from albumin solutions by using unmodified hyper-cross-linked polystyrene restricted access materials with crosslinking degrees varying from 100 to 400% (four of the acids are known to be markers of sepsis). The breakthrough volume of the most hydrophilic 3,4-dihydroxybenzoic acid rises as the sorbent bridging extent grows. Inversely, the breakthrough volume of the most hydrophobic 3-phenylpropionic acid was found to decrease considerably when the degree of crosslinking exceeds 200%. This unusual pattern is because of the superposition of two opposite tendencies. Increasing substitution extent of phenyls facilitates their π-π-interactions with polar compounds whereas rising density of the network reduces the accessibility of sorption sites to all solutes. Mini-cartridges containing 30 mg of an optimal sorbent take up the acids completely and reversibly, the recoveries being close to 100% even in the presence of high concentrations of albumin. By coupling the developed solid-phase extraction with high-performance liquid chromatography and diode array detection technique, we managed to determine quantitatively phenylcarboxylic acids in the serum of a healthy patient blood, and the recoveries varied from 93 to 100% while the limit of quantification was (4-9) × 10-7 M.
Top-30
Citations by journals
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Metabolites
1 publication, 50%
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Russian Chemical Reviews
1 publication, 50%
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Citations by publishers
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1
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Multidisciplinary Digital Publishing Institute (MDPI)
1 publication, 50%
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Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 publication, 50%
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1
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Popov A. et al. Trace enrichment of phenylcarboxylic acids from a model biological fluid and serum of human blood // Journal of Separation Science. 2019. jssc.201900258
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Popov A., Blinnikova Z. K., Tsyurupa M. P., Davankov V. Trace enrichment of phenylcarboxylic acids from a model biological fluid and serum of human blood // Journal of Separation Science. 2019. jssc.201900258
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TY - JOUR
DO - 10.1002/jssc.201900258
UR - https://doi.org/10.1002/jssc.201900258
TI - Trace enrichment of phenylcarboxylic acids from a model biological fluid and serum of human blood
T2 - Journal of Separation Science
AU - Blinnikova, Zinaida K
AU - Tsyurupa, Maria P
AU - Popov, Alekxander
AU - Davankov, Vadim
PY - 2019
DA - 2019/06/08 00:00:00
PB - Wiley
SN - 1615-9306
SN - 1615-9314
ER -
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@article{2019_Popov,
author = {Zinaida K Blinnikova and Maria P Tsyurupa and Alekxander Popov and Vadim Davankov},
title = {Trace enrichment of phenylcarboxylic acids from a model biological fluid and serum of human blood},
journal = {Journal of Separation Science},
year = {2019},
publisher = {Wiley},
month = {jun},
url = {https://doi.org/10.1002/jssc.201900258},
doi = {10.1002/jssc.201900258}
}