Mechanisms of action of ribavirin against distinct viruses
Publication type: Journal Article
Publication date: 2005-11-17
scimago Q1
wos Q1
SJR: 2.091
CiteScore: 20.0
Impact factor: 6.6
ISSN: 10529276, 10991654
DOI:
10.1002/rmv.483
PubMed ID:
16287208
Infectious Diseases
Virology
Abstract
The nucleoside analogue ribavirin has antiviral activity against many distinct viruses both in vitro and in vivo. Five distinct mechanisms have been proposed to explain the antiviral properties of ribavirin. These include both indirect mechanisms (inosine monophosphate dehydrogenase inhibition, immunomodulatory effects) and direct mechanisms (interference with RNA capping, polymerase inhibition, lethal mutagenesis). Recent concerns about bioterrorism have renewed interest in exploring the antiviral activity of ribavirin against unique viruses. In this paper, we review the proposed mechanisms of action with emphasis on recent discoveries, as well as the implications of ribavirin resistance. Evidence exists to support each of the five proposed mechanisms of action, and distinct virus/host combinations may preferentially favour one or more of these mechanisms during antiviral therapy.
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Metrics
444
Total citations:
444
Citations from 2024:
64
(14.41%)
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GOST
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Graci J. D., Cameron C. Mechanisms of action of ribavirin against distinct viruses // Reviews in Medical Virology. 2005. Vol. 16. No. 1. pp. 37-48.
GOST all authors (up to 50)
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Graci J. D., Cameron C. Mechanisms of action of ribavirin against distinct viruses // Reviews in Medical Virology. 2005. Vol. 16. No. 1. pp. 37-48.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1002/rmv.483
UR - https://doi.org/10.1002/rmv.483
TI - Mechanisms of action of ribavirin against distinct viruses
T2 - Reviews in Medical Virology
AU - Graci, Jason D.
AU - Cameron, Craig
PY - 2005
DA - 2005/11/17
PB - Wiley
SP - 37-48
IS - 1
VL - 16
PMID - 16287208
SN - 1052-9276
SN - 1099-1654
ER -
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BibTex (up to 50 authors)
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@article{2005_Graci,
author = {Jason D. Graci and Craig Cameron},
title = {Mechanisms of action of ribavirin against distinct viruses},
journal = {Reviews in Medical Virology},
year = {2005},
volume = {16},
publisher = {Wiley},
month = {nov},
url = {https://doi.org/10.1002/rmv.483},
number = {1},
pages = {37--48},
doi = {10.1002/rmv.483}
}
Cite this
MLA
Copy
Graci, Jason D., and Craig Cameron. “Mechanisms of action of ribavirin against distinct viruses.” Reviews in Medical Virology, vol. 16, no. 1, Nov. 2005, pp. 37-48. https://doi.org/10.1002/rmv.483.