Synthesis, Biological Evaluation, Molecular Docking, and Acid Dissociation Constant of New Bis‐1,2,3‐triazole Compounds
Yahya Nural
1, 2
,
Sadin Ozdemir
3
,
Mustafa Serkan Yalcin
4
,
Bunyamin Demir
2, 5
,
Hasan Atabey
6
,
Abdulilah Ece
7
,
Zeynel Seferoğlu
8
1
6
Mersin National Education Directorate Department of Analytical Chemistry Mersin Turkey
|
7
Тип публикации: Journal Article
Дата публикации: 2021-07-21
scimago Q3
wos Q3
БС2
SJR: 0.366
CiteScore: 3.0
Impact factor: 2.0
ISSN: 23656549
General Chemistry
Краткое описание
Bis-1,2,3-triazoles were synthesized by CuAAC click chemistry in 84–96 % yield. DNA cleavage, antioxidant, antibacterial and antifungal activities of the products were screened and molecular docking study was performed. The compounds showed excellent DNA cleavage activity while showing a valuable iron chelating activity and a moderate ability to scavenge the DPPH radical was also observed. The compounds exhibited antimicrobial activity with a MIC value in the range of 4–128 μg/mL. Four different pKa values of each product were determined in 20 % (v/v) DMSO-water at 25±0.1 °C.
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Nural Y. et al. Synthesis, Biological Evaluation, Molecular Docking, and Acid Dissociation Constant of New Bis‐1,2,3‐triazole Compounds // ChemistrySelect. 2021. Vol. 6. No. 28. pp. 6994-7001.
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Nural Y., Ozdemir S., Yalcin M. S., Demir B., Atabey H., Ece A., Seferoğlu Z. Synthesis, Biological Evaluation, Molecular Docking, and Acid Dissociation Constant of New Bis‐1,2,3‐triazole Compounds // ChemistrySelect. 2021. Vol. 6. No. 28. pp. 6994-7001.
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TY - JOUR
DO - 10.1002/slct.202101148
UR - https://doi.org/10.1002/slct.202101148
TI - Synthesis, Biological Evaluation, Molecular Docking, and Acid Dissociation Constant of New Bis‐1,2,3‐triazole Compounds
T2 - ChemistrySelect
AU - Nural, Yahya
AU - Ozdemir, Sadin
AU - Yalcin, Mustafa Serkan
AU - Demir, Bunyamin
AU - Atabey, Hasan
AU - Ece, Abdulilah
AU - Seferoğlu, Zeynel
PY - 2021
DA - 2021/07/21
PB - Wiley
SP - 6994-7001
IS - 28
VL - 6
SN - 2365-6549
ER -
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@article{2021_Nural,
author = {Yahya Nural and Sadin Ozdemir and Mustafa Serkan Yalcin and Bunyamin Demir and Hasan Atabey and Abdulilah Ece and Zeynel Seferoğlu},
title = {Synthesis, Biological Evaluation, Molecular Docking, and Acid Dissociation Constant of New Bis‐1,2,3‐triazole Compounds},
journal = {ChemistrySelect},
year = {2021},
volume = {6},
publisher = {Wiley},
month = {jul},
url = {https://doi.org/10.1002/slct.202101148},
number = {28},
pages = {6994--7001},
doi = {10.1002/slct.202101148}
}
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MLA
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Nural, Yahya, et al. “Synthesis, Biological Evaluation, Molecular Docking, and Acid Dissociation Constant of New Bis‐1,2,3‐triazole Compounds.” ChemistrySelect, vol. 6, no. 28, Jul. 2021, pp. 6994-7001. https://doi.org/10.1002/slct.202101148.