5-Indolylidene-2-iminothiazolidin-4-ones – Convenient Starting Compounds for Stereoselective Synthesis of Novel Dispirooxindole Derivatives
Alexei N Izmestev
1, 2
,
Andrey A Streltsov
1, 2, 3, 4
,
Valentina A Karnoukhova
5, 6
,
Natalya G Kolotyrkina
1, 2
,
Yurii A. Strelenko
1, 2
,
Angelina N. Kravchenko
1, 2
,
Galina A. Gazieva
1, 2
Publication type: Journal Article
Publication date: 2022-01-14
General Chemistry
Abstract
A convenient method for the synthesis of novel dispirooxindoles containing 2‐iminothiazolidin‐4‐one moiety has been proposed. The method relies on a 1,3‐dipolar cycloaddition of azomethine ylides generated in situ from paraformaldehyde and N‐alkyl amino acids including chiral ones to 5‐indolylidene‐2‐iminothiazolidin‐4‐ones. The method is suitable for preparing enantiomerically pure derivatives.
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Izmestev A. N. et al. 5-Indolylidene-2-iminothiazolidin-4-ones – Convenient Starting Compounds for Stereoselective Synthesis of Novel Dispirooxindole Derivatives // ChemistrySelect. 2022. Vol. 7. No. 2. e202104128
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Izmestev A. N., Streltsov A. A., Karnoukhova V. A., Kolotyrkina N. G., Strelenko Y. A., Kravchenko A. N., Gazieva G. A. 5-Indolylidene-2-iminothiazolidin-4-ones – Convenient Starting Compounds for Stereoselective Synthesis of Novel Dispirooxindole Derivatives // ChemistrySelect. 2022. Vol. 7. No. 2. e202104128
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TY - JOUR
DO - 10.1002/slct.202104128
UR - https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/slct.202104128
TI - 5-Indolylidene-2-iminothiazolidin-4-ones – Convenient Starting Compounds for Stereoselective Synthesis of Novel Dispirooxindole Derivatives
T2 - ChemistrySelect
AU - Izmestev, Alexei N
AU - Streltsov, Andrey A
AU - Karnoukhova, Valentina A
AU - Kolotyrkina, Natalya G
AU - Strelenko, Yurii A.
AU - Kravchenko, Angelina N.
AU - Gazieva, Galina A.
PY - 2022
DA - 2022/01/14
PB - Wiley
IS - 2
VL - 7
SN - 2365-6549
ER -
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@article{2022_Izmestev,
author = {Alexei N Izmestev and Andrey A Streltsov and Valentina A Karnoukhova and Natalya G Kolotyrkina and Yurii A. Strelenko and Angelina N. Kravchenko and Galina A. Gazieva},
title = {5-Indolylidene-2-iminothiazolidin-4-ones – Convenient Starting Compounds for Stereoselective Synthesis of Novel Dispirooxindole Derivatives},
journal = {ChemistrySelect},
year = {2022},
volume = {7},
publisher = {Wiley},
month = {jan},
url = {https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/slct.202104128},
number = {2},
pages = {e202104128},
doi = {10.1002/slct.202104128}
}