New Approach to Biologically Active Indolo[2,3-b]quinoxaline Derivatives through Intramolecular Oxidative Cyclodehydrogenation
Gusein A Sadykhov
1, 2
,
Danila V Belyaev
1, 3
,
Diana V. Vakhrusheva
3
,
Natalya I. Eremeeva
3
,
Marina G. Pervova
1
,
Gennady L. Rusinov
1, 2
,
Egor V Verbitskiy
1, 2
,
Oleg N. Chupakhin
1, 2
,
Valery N. Charushin
1, 2
Тип публикации: Journal Article
Дата публикации: 2022-05-10
scimago Q3
wos Q3
БС2
SJR: 0.366
CiteScore: 3.0
Impact factor: 2.0
ISSN: 23656549
General Chemistry
Краткое описание
A convenient synthetic protocol to antiviral agent B‐220 and a series of similar indolo[2,3‐b]quinoxaline derivatives has been developed. This synthetic approach is based on Buchwald‐Hartwig cross‐coupling and subsequent annulation by intramolecular oxidative cyclodehydrogenation. For the first time, 6H‐indolo[2,3‐b]quinoxaline amine derivatives were evaluated for antimycobacterial activity. The moderate bacteriostatic effect against Mycobacterium tuberculosis H37Rv was found. A plausible mechanism of antibacterial action was elucidated by the molecular docking.
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Sadykhov G. A. et al. New Approach to Biologically Active Indolo[2,3-b]quinoxaline Derivatives through Intramolecular Oxidative Cyclodehydrogenation // ChemistrySelect. 2022. Vol. 7. No. 18.
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Sadykhov G. A., Belyaev D. V., Vakhrusheva D. V., Eremeeva N. I., Khramtsova E. E., Pervova M. G., Rusinov G. L., Verbitskiy E. V., Chupakhin O. N., Charushin V. N. New Approach to Biologically Active Indolo[2,3-b]quinoxaline Derivatives through Intramolecular Oxidative Cyclodehydrogenation // ChemistrySelect. 2022. Vol. 7. No. 18.
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TY - JOUR
DO - 10.1002/slct.202200497
UR - https://doi.org/10.1002/slct.202200497
TI - New Approach to Biologically Active Indolo[2,3-b]quinoxaline Derivatives through Intramolecular Oxidative Cyclodehydrogenation
T2 - ChemistrySelect
AU - Sadykhov, Gusein A
AU - Belyaev, Danila V
AU - Vakhrusheva, Diana V.
AU - Eremeeva, Natalya I.
AU - Khramtsova, Ekaterina E
AU - Pervova, Marina G.
AU - Rusinov, Gennady L.
AU - Verbitskiy, Egor V
AU - Chupakhin, Oleg N.
AU - Charushin, Valery N.
PY - 2022
DA - 2022/05/10
PB - Wiley
IS - 18
VL - 7
SN - 2365-6549
ER -
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@article{2022_Sadykhov,
author = {Gusein A Sadykhov and Danila V Belyaev and Diana V. Vakhrusheva and Natalya I. Eremeeva and Ekaterina E Khramtsova and Marina G. Pervova and Gennady L. Rusinov and Egor V Verbitskiy and Oleg N. Chupakhin and Valery N. Charushin},
title = {New Approach to Biologically Active Indolo[2,3-b]quinoxaline Derivatives through Intramolecular Oxidative Cyclodehydrogenation},
journal = {ChemistrySelect},
year = {2022},
volume = {7},
publisher = {Wiley},
month = {may},
url = {https://doi.org/10.1002/slct.202200497},
number = {18},
doi = {10.1002/slct.202200497}
}