ChemistrySelect, volume 7, issue 18

New Approach to Biologically Active Indolo[2,3-b]quinoxaline Derivatives through Intramolecular Oxidative Cyclodehydrogenation

Sadykhov Gusein A ^{1, 2}

Belyaev Danila V ^{1, 3}

Vakhrusheva Diana V. ³

Eremeeva Natalya I. ³

Khramtsova Ekaterina E ⁴

Pervova Marina G. ¹

Rusinov Gennady L. ^{1, 2}

Verbitskiy Egor V ^{1, 2}

Chupakhin Oleg N. ^{1, 2}

Charushin Valery N. ^{1, 2}

Hide authors affiliations Show authors affiliations: 4 affiliations

Postovsky Institute of Organic Synthesis Ural Branch of the Russian Academy of Sciences S. Kovalevskoy Str., 22 Ekaterinburg 620137 Russia |

Ural Federal University Mira St. 19 Ekaterinburg 620002 Russia |

Ural Research Institute for Phthisiopulmonology – the Branch of National Medical Research Center for Phthisiopulmonology and Infection Diseases 22 Parts'ezda St., 50 Ekaterinburg 620039 Russia |

⁴

Department of Chemistry Perm State University Bukireva St., 15 Perm 614990 Russia |

Publication type: Journal Article

Publication date: 2022-05-10

Wiley

Journal: ChemistrySelect

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Impact factor: 2.1

ISSN: 23656549

DOI: 10.1002/slct.202200497

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General Chemistry

Abstract

A convenient synthetic protocol to antiviral agent B‐220 and a series of similar indolo[2,3‐b]quinoxaline derivatives has been developed. This synthetic approach is based on Buchwald‐Hartwig cross‐coupling and subsequent annulation by intramolecular oxidative cyclodehydrogenation. For the first time, 6H‐indolo[2,3‐b]quinoxaline amine derivatives were evaluated for antimycobacterial activity. The moderate bacteriostatic effect against Mycobacterium tuberculosis H₃₇Rv was found. A plausible mechanism of antibacterial action was elucidated by the molecular docking.

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	1
Chemistry of Heterocyclic Compounds	Chemistry of Heterocyclic Compounds, 1, 33.33% Chemistry of Heterocyclic Compounds 1 publication, 33.33%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 1, 33.33% International Journal of Molecular Sciences 1 publication, 33.33%
Journal of Molecular Structure	Journal of Molecular Structure, 1, 33.33% Journal of Molecular Structure 1 publication, 33.33%
	1

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Springer Nature	Springer Nature, 1, 33.33% Springer Nature 1 publication, 33.33%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 1, 33.33% Multidisciplinary Digital Publishing Institute (MDPI) 1 publication, 33.33%
Elsevier	Elsevier, 1, 33.33% Elsevier 1 publication, 33.33%
	1

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Sadykhov G. A. et al. New Approach to Biologically Active Indolo[2,3-b]quinoxaline Derivatives through Intramolecular Oxidative Cyclodehydrogenation // ChemistrySelect. 2022. Vol. 7. No. 18.

GOST all authors (up to 50) Copy

Sadykhov G. A., Belyaev D. V., Vakhrusheva D. V., Eremeeva N. I., Khramtsova E. E., Pervova M. G., Rusinov G. L., Verbitskiy E. V., Chupakhin O. N., Charushin V. N. New Approach to Biologically Active Indolo[2,3-b]quinoxaline Derivatives through Intramolecular Oxidative Cyclodehydrogenation // ChemistrySelect. 2022. Vol. 7. No. 18.

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RIS Copy

TY - JOUR

DO - 10.1002/slct.202200497

UR - https://doi.org/10.1002%2Fslct.202200497

TI - New Approach to Biologically Active Indolo[2,3-b]quinoxaline Derivatives through Intramolecular Oxidative Cyclodehydrogenation

T2 - ChemistrySelect

AU - Belyaev, Danila V

AU - Eremeeva, Natalya I.

AU - Khramtsova, Ekaterina E

AU - Pervova, Marina G.

AU - Charushin, Valery N.

AU - Sadykhov, Gusein A

AU - Vakhrusheva, Diana V.

AU - Rusinov, Gennady L.

AU - Verbitskiy, Egor V

AU - Chupakhin, Oleg N.

PY - 2022

DA - 2022/05/10 00:00:00

PB - Wiley

IS - 18

VL - 7

SN - 2365-6549

ER -

BibTex

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BibTex Copy

@article{2022_Sadykhov,

author = {Danila V Belyaev and Natalya I. Eremeeva and Ekaterina E Khramtsova and Marina G. Pervova and Valery N. Charushin and Gusein A Sadykhov and Diana V. Vakhrusheva and Gennady L. Rusinov and Egor V Verbitskiy and Oleg N. Chupakhin},

title = {New Approach to Biologically Active Indolo[2,3-b]quinoxaline Derivatives through Intramolecular Oxidative Cyclodehydrogenation},

journal = {ChemistrySelect},

year = {2022},

volume = {7},

publisher = {Wiley},

month = {may},

url = {https://doi.org/10.1002%2Fslct.202200497},

number = {18},

doi = {10.1002/slct.202200497}

}

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Publisher

Wiley

Journal

ChemistrySelect

Quartile SCImago

Quartile WOS

Impact factor

2.1

ISSN

23656549 (Electronic)

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