Wiley
ChemistrySelect
,  volume 8 ,  issue 43 ,  publication number e202303892

A New Efficient One‐Pot Three‐Component Synthesis of Diverse Pyrido[1,2‐a]pyrimidines

Publication type: Journal Article
Publication date: 2023-11-14
Wiley
scimago Q3
wos Q3
SJR: 0.366
CiteScore: 3.0
Impact factor: 2.0
ISSN: 23656549
General Chemistry
Abstract

The pyrido[1,2‐ a ]pyrimidine scaffold has great potential for the creation of bioactive substances. Here we propose a simple, cost‐effective, efficient approach to forming this core based on a one‐pot three‐component reaction of commercially available 3‐oxo esters, α,β‐unsaturated aldehydes and 1,3‐diaminopropane. The developed strategy makes it possible to obtain diverse pyrido[1,2‐ a ]pyrimidines thanks to alternative intramolecular cyclization pathways that depend on the substituent in the 3‐oxo ester. Their diastereomeric structure was determined using NMR spectroscopy and XRD. A mechanism for the formation of new pyrido[1,2‐ a ]pyridines has been proposed.

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Goryaeva M. V. et al. A New Efficient One‐Pot Three‐Component Synthesis of Diverse Pyrido[1,2‐a]pyrimidines // ChemistrySelect. 2023. Vol. 8. No. 43. e202303892
GOST all authors (up to 50) Copy
Goryaeva M. V., Kushch S. O., Surnina E. A., Burgart Y. V., Ezhikova M. A., Kodess M. I., Slepukhin P. A., Saloutin V. A New Efficient One‐Pot Three‐Component Synthesis of Diverse Pyrido[1,2‐a]pyrimidines // ChemistrySelect. 2023. Vol. 8. No. 43. e202303892
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RIS Copy
TY - JOUR
DO - 10.1002/slct.202303892
UR - https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/slct.202303892
TI - A New Efficient One‐Pot Three‐Component Synthesis of Diverse Pyrido[1,2‐a]pyrimidines
T2 - ChemistrySelect
AU - Goryaeva, Marina V.
AU - Kushch, Svetlana O
AU - Surnina, Elena A
AU - Burgart, Yanina V.
AU - Ezhikova, Marina A
AU - Kodess, Mikhail I.
AU - Slepukhin, Pavel A.
AU - Saloutin, Victor
PY - 2023
DA - 2023/11/14
PB - Wiley
IS - 43
VL - 8
SN - 2365-6549
ER -
BibTex
Cite this
BibTex (up to 50 authors) Copy
@article{2023_Goryaeva,
author = {Marina V. Goryaeva and Svetlana O Kushch and Elena A Surnina and Yanina V. Burgart and Marina A Ezhikova and Mikhail I. Kodess and Pavel A. Slepukhin and Victor Saloutin},
title = {A New Efficient One‐Pot Three‐Component Synthesis of Diverse Pyrido[1,2‐a]pyrimidines},
journal = {ChemistrySelect},
year = {2023},
volume = {8},
publisher = {Wiley},
month = {nov},
url = {https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/slct.202303892},
number = {43},
pages = {e202303892},
doi = {10.1002/slct.202303892}
}