Teratology

, volume 17 , issue 1 , pages 93-101

Teratogenic effects of ribavirin on hamster and rat embryos

Vergil H. Ferm ¹

Calvin Willhite ¹

Lawrence Kilham ¹

Hide authors affiliations Show authors affiliations: 1 affiliation

Departments of Anatomy/Cytology and Microbiology, Dartmouth Medical School, Hanover, New Hampshire 03755 |

Publication type: Journal Article

Publication date: 1978-02-01

Wiley

Teratology

SJR: —

CiteScore: —

Impact factor: —

ISSN: 00403709, 10969926

DOI: 10.1002/tera.1420170117

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PubMed ID: 415379

Health, Toxicology and Mutagenesis

Developmental Biology

Toxicology

Embryology

Abstract

Ribavirin, a synthetic nucleoside with marked antiviral activity, induced developmental malformations when administered to pregnant hamsters by oral, intraperitoneal or intravenous routes. Abnormalities of the limbs, eyes and brain were the most common defects found in the hamster. Higher doses (about 10 x) were required to induce anomalies in rat embryos and the malformations were generally restricted to the head region. In both rats and hamsters oral administration of the drug seemed to be more teratogenic than administration by other routes suggesting that metabolism of ribavirin in the maternal gastro-intestinal tract and/or liver may change it into its active form.

Found

1 citation

Yarovaya Olga

PhD in Chemistry

117 publications, 1 813 citations, 14 reviews

h-index: 23

N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of the Siberian Branch of the Russian Academy of Sciences

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GOST |

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GOST Copy

Ferm V. H., Willhite C., Kilham L. Teratogenic effects of ribavirin on hamster and rat embryos // Teratology. 1978. Vol. 17. No. 1. pp. 93-101.

GOST all authors (up to 50) Copy

Ferm V. H., Willhite C., Kilham L. Teratogenic effects of ribavirin on hamster and rat embryos // Teratology. 1978. Vol. 17. No. 1. pp. 93-101.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1002/tera.1420170117

UR - https://doi.org/10.1002/tera.1420170117

TI - Teratogenic effects of ribavirin on hamster and rat embryos

T2 - Teratology

AU - Ferm, Vergil H.

AU - Willhite, Calvin

AU - Kilham, Lawrence

PY - 1978

DA - 1978/02/01

PB - Wiley

SP - 93-101

IS - 1

VL - 17

PMID - 415379

SN - 0040-3709

SN - 1096-9926

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{1978_Ferm,

author = {Vergil H. Ferm and Calvin Willhite and Lawrence Kilham},

title = {Teratogenic effects of ribavirin on hamster and rat embryos},

journal = {Teratology},

year = {1978},

volume = {17},

publisher = {Wiley},

month = {feb},

url = {https://doi.org/10.1002/tera.1420170117},

number = {1},

pages = {93--101},

doi = {10.1002/tera.1420170117}

}

MLA

Cite this

MLA Copy

Ferm, Vergil H., et al. “Teratogenic effects of ribavirin on hamster and rat embryos.” Teratology, vol. 17, no. 1, Feb. 1978, pp. 93-101. https://doi.org/10.1002/tera.1420170117.

Publisher

Wiley

Journal

Teratology

SJR

—

CiteScore

—

Impact factor

—

ISSN

00403709 (Print)

10969926 (Electronic)