Bakers′ Yeast Reduction of α-Diketones: Investigation and Control of the Enzymatic Pathway
Publication type: Journal Article
Publication date: 1993-09-01
scimago Q1
wos Q1
SJR: 0.786
CiteScore: 8.3
Impact factor: 4.7
ISSN: 00452068, 10902120
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Abstract
Abstract Optically pure α-hydroxyketones and α-diols are obtained through a regio- and stereocontrol of the reduction of acyclic α-diketones by bakers′ yeast. An investigation of the enzymatic system clearly demonstrates the role of two enzymes operating in sequence. An alcohol dehydrogenase is implicated in the initial reduction of the α-diketone, and the resulting α-hydroxyketone is subsequently reduced by a glycerol dehydrogenase. The first reductive step is found to direct the stereochemical outcome of the entire reaction.
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21
Total citations:
21
Citations from 2025:
1
(4.76%)
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GOST
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Besse P. et al. Bakers′ Yeast Reduction of α-Diketones: Investigation and Control of the Enzymatic Pathway // Bioorganic Chemistry. 1993. Vol. 21. No. 3. pp. 342-353.
GOST all authors (up to 50)
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Besse P., BOLTE J., Fauve A., Veschambre H. Bakers′ Yeast Reduction of α-Diketones: Investigation and Control of the Enzymatic Pathway // Bioorganic Chemistry. 1993. Vol. 21. No. 3. pp. 342-353.
Cite this
RIS
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TY - JOUR
DO - 10.1006/bioo.1993.1029
UR - https://doi.org/10.1006/bioo.1993.1029
TI - Bakers′ Yeast Reduction of α-Diketones: Investigation and Control of the Enzymatic Pathway
T2 - Bioorganic Chemistry
AU - Besse, P.
AU - BOLTE, J.
AU - Fauve, A.
AU - Veschambre, H.
PY - 1993
DA - 1993/09/01
PB - Elsevier
SP - 342-353
IS - 3
VL - 21
SN - 0045-2068
SN - 1090-2120
ER -
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BibTex (up to 50 authors)
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@article{1993_Besse,
author = {P. Besse and J. BOLTE and A. Fauve and H. Veschambre},
title = {Bakers′ Yeast Reduction of α-Diketones: Investigation and Control of the Enzymatic Pathway},
journal = {Bioorganic Chemistry},
year = {1993},
volume = {21},
publisher = {Elsevier},
month = {sep},
url = {https://doi.org/10.1006/bioo.1993.1029},
number = {3},
pages = {342--353},
doi = {10.1006/bioo.1993.1029}
}
Cite this
MLA
Copy
Besse, P., et al. “Bakers′ Yeast Reduction of α-Diketones: Investigation and Control of the Enzymatic Pathway.” Bioorganic Chemistry, vol. 21, no. 3, Sep. 1993, pp. 342-353. https://doi.org/10.1006/bioo.1993.1029.