Increased Peroxidation and Reduced Antioxidant Enzyme Activity in Alzheimer's Disease
Publication type: Journal Article
Publication date: 1998-03-01
scimago Q1
wos Q1
SJR: 1.499
CiteScore: 8.7
Impact factor: 4.2
ISSN: 00144886, 10902430
PubMed ID:
9514828
Neurology
Developmental Neuroscience
Abstract
The overall peroxidation activity in brain tissue by region from patients with Alzheimer's disease (AD) and age-matched controls was determined employing the thiobarbituric acid-reactive substances (TBARS) assay, a measure of lipid peroxidation, followed by a determination the activities of the antioxidant enzymes Cu/Zn superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT), in the frontal, temporal, and cerebellar cortex of 10 AD and 9 control brains. The level of TBARS was elevated in all regions, with particular statistical significance in the temporal cortex when compared to age-matched controls. SOD activity was significantly decreased in AD frontal and AD temporal cortex, while catalase activity was significantly decreased in AD temporal cortex. There was no significant difference in GSH-Px activity found in any of the regions examined. This study supports the theory that in AD the brain is affected by increased oxidative stress which, when combined with a decrease in SOD activity, produces oxidative alterations, seen most significantly in temporal cortex in AD, where the pathophysiologic changes are most severe.
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Metrics
393
Total citations:
393
Citations from 2024:
24
(6.11%)
Cite this
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BibTex |
MLA
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GOST
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Marcus D. L. et al. Increased Peroxidation and Reduced Antioxidant Enzyme Activity in Alzheimer's Disease // Experimental Neurology. 1998. Vol. 150. No. 1. pp. 40-44.
GOST all authors (up to 50)
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MARCUS D. S., Simpson T. E., Rodriguez C., Simberkoff K., Tsai J. S., Strafaci J. A., FREEDMAN M. R. Increased Peroxidation and Reduced Antioxidant Enzyme Activity in Alzheimer's Disease // Experimental Neurology. 1998. Vol. 150. No. 1. pp. 40-44.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1006/exnr.1997.6750
UR - https://doi.org/10.1006/exnr.1997.6750
TI - Increased Peroxidation and Reduced Antioxidant Enzyme Activity in Alzheimer's Disease
T2 - Experimental Neurology
AU - MARCUS, DAVID S.
AU - Simpson, Thomas E.
AU - Rodriguez, Charles
AU - Simberkoff, Katherine
AU - Tsai, Jir S.
AU - Strafaci, James A
AU - FREEDMAN, MICHAEL R.
PY - 1998
DA - 1998/03/01
PB - Elsevier
SP - 40-44
IS - 1
VL - 150
PMID - 9514828
SN - 0014-4886
SN - 1090-2430
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{1998_Marcus,
author = {DAVID S. MARCUS and Thomas E. Simpson and Charles Rodriguez and Katherine Simberkoff and Jir S. Tsai and James A Strafaci and MICHAEL R. FREEDMAN},
title = {Increased Peroxidation and Reduced Antioxidant Enzyme Activity in Alzheimer's Disease},
journal = {Experimental Neurology},
year = {1998},
volume = {150},
publisher = {Elsevier},
month = {mar},
url = {https://doi.org/10.1006/exnr.1997.6750},
number = {1},
pages = {40--44},
doi = {10.1006/exnr.1997.6750}
}
Cite this
MLA
Copy
Marcus, David L., et al. “Increased Peroxidation and Reduced Antioxidant Enzyme Activity in Alzheimer's Disease.” Experimental Neurology, vol. 150, no. 1, Mar. 1998, pp. 40-44. https://doi.org/10.1006/exnr.1997.6750.