Open Access
The Detection and Analysis of Chromosome Fragile Sites
Publication type: Book Chapter
Publication date: 2017-10-17
scimago Q4
SJR: 0.354
CiteScore: 2.1
Impact factor: —
ISSN: 10643745, 19406029
PubMed ID:
29043642
Abstract
A fragile site is a chromosomal locus that is prone to form a gap or constriction visible within a condensed metaphase chromosome, particularly following exposure of cells to DNA replication stress. Based on their frequency, fragile sites are classified as either common (CFSs; present in all individuals) or rare (RFSs; present in only a few individuals). Interest in fragile sites has remained high since their discovery in 1965, because of their association with human disease. CFSs are recognized as drivers of oncogene activation and genome instability in cancer cells, while some RFSs are associated with neurodegenerative diseases. This review summaries our current understanding of the nature and causes of fragile site “expression”, including the recently characterized phenomenon of telomere fragility. In particular, we focus on a description of the methodologies and technologies for detection and analysis of chromosome fragile sites.
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Total citations:
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Citations from 2024:
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(16.67%)
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GOST
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Bjerregaard V. A. et al. The Detection and Analysis of Chromosome Fragile Sites // Methods in Molecular Biology. 2017. Vol. 1672. pp. 471-482.
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Bjerregaard V. A., Özer Ö., HICKSON I. D., Liu Y. The Detection and Analysis of Chromosome Fragile Sites // Methods in Molecular Biology. 2017. Vol. 1672. pp. 471-482.
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TY - GENERIC
DO - 10.1007/978-1-4939-7306-4_31
UR - https://doi.org/10.1007/978-1-4939-7306-4_31
TI - The Detection and Analysis of Chromosome Fragile Sites
T2 - Methods in Molecular Biology
AU - Bjerregaard, Victoria A
AU - Özer, Özgün
AU - HICKSON, Ian D.
AU - Liu, Ying
PY - 2017
DA - 2017/10/17
PB - Springer Nature
SP - 471-482
VL - 1672
PMID - 29043642
SN - 1064-3745
SN - 1940-6029
ER -
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@incollection{2017_Bjerregaard,
author = {Victoria A Bjerregaard and Özgün Özer and Ian D. HICKSON and Ying Liu},
title = {The Detection and Analysis of Chromosome Fragile Sites},
publisher = {Springer Nature},
year = {2017},
volume = {1672},
pages = {471--482},
month = {oct}
}