Handbook of Experimental Pharmacology, pages 97-115
Retro-Retinoids: Metabolism and Action
Vakiani E., Buck J.
Publication type: Book Chapter
Publication date: 1999-01-01
scimago Q2
SJR: 0.303
CiteScore: 5.2
Impact factor: —
ISSN: 01712004, 18650325
Abstract
In a classic histological study published in 1925 Wolbach and Howe described the widespread pathology associated with vitamin A deficiency in rats. The reported abnormalities included stunted growth, blindness, keratinization of the epithelial linings of the respiratory and alimentary tracts, defective development of testis and atrophy of the central and peripheral lymphoid organs. Subsequent studies with vitamin A deficient animals have confirmed these findings and have established a critical role for retinol in the normal development and maintenance of most tissues.
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