Springer Proceedings in Physics, pages 65-85
Synthesis of 4-Substituted 2,2′; 6′,2″-Terpyridine Copper Complexes and Study of Their Anti-cancer Activities
Bhuvanagiri Srikanth
1
,
Dripta De Joarder
1
Publication type: Book Chapter
Publication date: 2024-12-29
Journal:
Springer Proceedings in Physics
SJR: 0.135
CiteScore: 0.4
Impact factor: —
ISSN: 09308989, 18674941
Abstract
Copper terpyridine complexes represent a class of coordination compounds that have drawn substantial attention due to their diverse chemical properties and potential applications in various fields, particularly in medicinal chemistry. These complexes have also demonstrated remarkable potential as anti-cancer agents due to their ability to interact with biological molecules and modulate cellular processes relevant to cancer progression. One of the key mechanisms underlying their anti-cancer activities is their interaction with DNA. These complexes can bind to DNA through intercalation or groove binding, leading to structural changes that interfere with DNA replication and transcription, ultimately inducing apoptosis in cancer cells. Moreover, copper is an essential trace element in biological systems, playing a crucial role in various physiological processes. However, dysregulation of copper homeostasis has been implicated in cancer development and progression. Copper terpyridine complexes offer a unique opportunity to exploit this dysregulation by targeting copper-dependent pathways in cancer cells while sparing normal cells. By chelating copper ions, these complexes can disrupt copper-mediated signaling pathways involved in angiogenesis, metastasis, and tumor growth, thereby exerting selective cytotoxic effects on cancer cells. Furthermore, copper terpyridine complexes can exhibit redox activity, leading to the generation of reactive oxygen species (ROS) within cancer cells. Elevated levels of ROS can induce oxidative stress, causing damage to cellular components and triggering apoptosis in cancer cells. This pro-oxidant activity makes copper terpyridine complexes particularly effective against cancer cells with high levels of oxidative stress defense mechanisms. Continued research is being carried out for the synthesis and optimization of copper terpyridine complexes holds promise for the development of innovative cancer treatments with improved efficacy and selectivity. This chapter explores the synthesis of copper terpyridine complexes and elucidates their importance in anti-cancer activities that have been done in the last eight years.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.