pages 129-133

HBOT in Aging and Regeneration

MANOJ GUPTA 1
Indumathi Somasundaram 2
1
 
Sailee Hospital and Diagnostic Centre, Prana Hyperbaric Oxygen Therapy Centre, Mumbai, Maharashtra, India
2
 
Department of Biotechnology Engineering, Kolhapur Institute of Technology’s College of Engineering, Kolhapur, Maharashtra, India
Publication typeBook Chapter
Publication date2023-01-01
Abstract
HBOT has been implemented in a large number of clinical conditions where it is found to be highly beneficial. HBOT enables increased bioavailability of oxygen throughout the tissues by elevating the partial pressure of oxygen in the blood. The therapeutic effects of HBOT arise from the direct effect of oxygen in preservation of oxidative environment and indirectly by modulating a wide array of physiological functions. HBOT has gained attention as an anti-ageing therapy due to its ability to modulate the physiological and molecular functions directly involved in the process of ageing. The regenerative effect of HBOT is evident in its application in treatment of wound healing and repair. In general, HBOT can affect the cellular micro-environment to modulate functions like cell senescence, proteostasis, telomerase activity and mitochondrial function which may result in a rejuvenating effect on body. However, further research is required to understand the role of oxygen in the process of ageing.
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