A stability-indicating HPLC method for the determination of 17β-estradiol-3-phosphate in an ophthalmic solution
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Pharmaceutical Development Department, IOLAB Corporation (a Johnson & Johnson Company), Claremont, USA
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Publication type: Journal Article
Publication date: 1995-02-01
scimago Q3
wos Q4
SJR: 0.278
CiteScore: 2.7
Impact factor: 1.3
ISSN: 00095893, 16121112
Organic Chemistry
Biochemistry
Clinical Biochemistry
Analytical Chemistry
Abstract
A reversed-phase high-performance liquid chromatographic (HPLC) procedure using ultra-violet (UV) detection for the analysis of 17β-estradiol-3-phosphate in an ophthalmic solution is reported. The method is selective, accurate, and reproducible. The peak area versus 17β-estradiol-3-phosphate concentration is linear over the range of 50–150% of its label claim of 1.0 mg/mL, with a detection limit of 20 ng/mL. The mean absolute recovery of 17β-estradiol-3-phosphate using the described method is 99.8±0.6% (mean ±SD, n=10). A stress study with heat, acid, base and UV radiation indicates that the method is stability-indicating with no interference from excipients or degradation products.
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Miller R. B., Chen C. A stability-indicating HPLC method for the determination of 17β-estradiol-3-phosphate in an ophthalmic solution // Chromatographia. 1995. Vol. 40. No. 3-4. pp. 204-206.
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Miller R. B., Chen C. A stability-indicating HPLC method for the determination of 17β-estradiol-3-phosphate in an ophthalmic solution // Chromatographia. 1995. Vol. 40. No. 3-4. pp. 204-206.
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TY - JOUR
DO - 10.1007/bf02272172
UR - https://doi.org/10.1007/bf02272172
TI - A stability-indicating HPLC method for the determination of 17β-estradiol-3-phosphate in an ophthalmic solution
T2 - Chromatographia
AU - Miller, R. B.
AU - Chen, C
PY - 1995
DA - 1995/02/01
PB - Springer Nature
SP - 204-206
IS - 3-4
VL - 40
SN - 0009-5893
SN - 1612-1112
ER -
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BibTex (up to 50 authors)
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@article{1995_Miller,
author = {R. B. Miller and C Chen},
title = {A stability-indicating HPLC method for the determination of 17β-estradiol-3-phosphate in an ophthalmic solution},
journal = {Chromatographia},
year = {1995},
volume = {40},
publisher = {Springer Nature},
month = {feb},
url = {https://doi.org/10.1007/bf02272172},
number = {3-4},
pages = {204--206},
doi = {10.1007/bf02272172}
}
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MLA
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Miller, R. B., and C Chen. “A stability-indicating HPLC method for the determination of 17β-estradiol-3-phosphate in an ophthalmic solution.” Chromatographia, vol. 40, no. 3-4, Feb. 1995, pp. 204-206. https://doi.org/10.1007/bf02272172.