Aporphine alkaloids and their reversal activity of multidrug resistance (MDR) from the stems and rhizomes ofSinomenium acutum
Тип публикации: Journal Article
Дата публикации: 2006-08-01
scimago Q1
wos Q1
БС1
SJR: 1.87
CiteScore: 14.4
Impact factor: 7.5
ISSN: 02536269, 19763786
PubMed ID:
16964757
Organic Chemistry
Drug Discovery
Molecular Medicine
Краткое описание
Chromatographic separation of the MeOH extract from the stems and rhizomes ofSinomemium acutum led to the isolation of nine alkaloids and a lignan. Their structures were determined to be dauriporphine (1), bianfugecine (2), dauriporphinoline (3), menisporphine (4), (−)-syringaresinol (5), N-feruloyltyramine (6), acutumine (7), dauricumine (8), sinomenine (9), and magnoflorine (10) by spectroscopic means. These compounds were examined for their P-gp mediated MDR reversal activity in human cancer cells. Compound1 showed the most potent P-gp MDR inhibition activity with an ED50 value 0.03 μg/mL and 0.00010 μg/mL in the MES-SA/DX5 and HCT15 cells, respectively.
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Min Y., Choi S., Lee K. Aporphine alkaloids and their reversal activity of multidrug resistance (MDR) from the stems and rhizomes ofSinomenium acutum // Archives of Pharmacal Research. 2006. Vol. 29. No. 8. pp. 627-632.
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Min Y., Choi S., Lee K. Aporphine alkaloids and their reversal activity of multidrug resistance (MDR) from the stems and rhizomes ofSinomenium acutum // Archives of Pharmacal Research. 2006. Vol. 29. No. 8. pp. 627-632.
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TY - JOUR
DO - 10.1007/bf02968246
UR - https://doi.org/10.1007/bf02968246
TI - Aporphine alkaloids and their reversal activity of multidrug resistance (MDR) from the stems and rhizomes ofSinomenium acutum
T2 - Archives of Pharmacal Research
AU - Min, Yong-Deuk
AU - Choi, Sang-Un
AU - Lee, Kang-Ro
PY - 2006
DA - 2006/08/01
PB - Pharmaceutical Society of Korea
SP - 627-632
IS - 8
VL - 29
PMID - 16964757
SN - 0253-6269
SN - 1976-3786
ER -
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@article{2006_Min,
author = {Yong-Deuk Min and Sang-Un Choi and Kang-Ro Lee},
title = {Aporphine alkaloids and their reversal activity of multidrug resistance (MDR) from the stems and rhizomes ofSinomenium acutum},
journal = {Archives of Pharmacal Research},
year = {2006},
volume = {29},
publisher = {Pharmaceutical Society of Korea},
month = {aug},
url = {https://doi.org/10.1007/bf02968246},
number = {8},
pages = {627--632},
doi = {10.1007/bf02968246}
}
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Min, Yong-Deuk, et al. “Aporphine alkaloids and their reversal activity of multidrug resistance (MDR) from the stems and rhizomes ofSinomenium acutum.” Archives of Pharmacal Research, vol. 29, no. 8, Aug. 2006, pp. 627-632. https://doi.org/10.1007/bf02968246.