Medicinal Chemistry Research

, volume 16 , issue 4 , pages 179-187

Synthesis and evaluation of 1-benzhydryl-sulfonyl-piperazine derivatives as inhibitors of MDA-MB-231 human breast cancer cell proliferation

C. S. Ananda Kumar ¹

S. Nanjunda Swamy ¹

N. R. Thimmegowda ¹

S. B. Benaka Prasad ¹

George W. Yip ²

K. S. Rangappa ^{1, 3}

Hide authors affiliations Show authors affiliations: 3 affiliations

Department of studies in Chemistry, University of Mysore, Mysore, India |

Department of Anatomy, National University of Singapore, Singapore, Singapore |

DOS in Chemistry, University of Mysore, Mysore, India |

Publication type: Journal Article

Publication date: 2007-08-01

Springer Nature

Medicinal Chemistry Research

scimago Q2

wos Q3

SJR: 0.470

CiteScore: 5.1

Impact factor: 3.1

ISSN: 10542523, 15548120

DOI: 10.1007/s00044-007-9022-y

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Organic Chemistry

General Pharmacology, Toxicology and Pharmaceutics

Abstract

A series of novel 1-benzhydryl-sulfonyl-piperazine derivatives 7(a-e) were designed by a nucleophilic substitution reaction of 1-benzhydryl-piperazine with various sulfonyl chlorides and characterized by 1H nuclear magnetic resonance (NMR), liquid chromatography mass spectrometry (LC/MS), Fourier-transform infrared (FTIR), and elemental analysis. Our research is focused on identifying synthetically occurring chemotherapeutic substances capable of inhibiting, retarding, or reversing the process of multistage carcinogenesis. The title compounds were evaluated for their efficacy in inhibiting MDA-MB-231 breast cancer cell proliferation. Compound 1-benzhydryl-4-(4-tert-butyl-benzenesulfonyl)-piperazine (7d) showed significant inhibitory activity.

Found

1 citation

Shivaramu Prasanna

71 publications, 1 042 citations, 9 reviews

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GOST |

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GOST Copy

Ananda Kumar C. S. et al. Synthesis and evaluation of 1-benzhydryl-sulfonyl-piperazine derivatives as inhibitors of MDA-MB-231 human breast cancer cell proliferation // Medicinal Chemistry Research. 2007. Vol. 16. No. 4. pp. 179-187.

GOST all authors (up to 50) Copy

Ananda Kumar C. S., Nanjunda Swamy S., Thimmegowda N. R., Benaka Prasad S. B., Yip G. W., Rangappa K. S. Synthesis and evaluation of 1-benzhydryl-sulfonyl-piperazine derivatives as inhibitors of MDA-MB-231 human breast cancer cell proliferation // Medicinal Chemistry Research. 2007. Vol. 16. No. 4. pp. 179-187.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1007/s00044-007-9022-y

UR - https://doi.org/10.1007/s00044-007-9022-y

TI - Synthesis and evaluation of 1-benzhydryl-sulfonyl-piperazine derivatives as inhibitors of MDA-MB-231 human breast cancer cell proliferation

T2 - Medicinal Chemistry Research

AU - Ananda Kumar, C. S.

AU - Nanjunda Swamy, S.

AU - Thimmegowda, N. R.

AU - Benaka Prasad, S. B.

AU - Yip, George W.

AU - Rangappa, K. S.

PY - 2007

DA - 2007/08/01

PB - Springer Nature

SP - 179-187

IS - 4

VL - 16

SN - 1054-2523

SN - 1554-8120

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2007_Ananda Kumar,

author = {C. S. Ananda Kumar and S. Nanjunda Swamy and N. R. Thimmegowda and S. B. Benaka Prasad and George W. Yip and K. S. Rangappa},

title = {Synthesis and evaluation of 1-benzhydryl-sulfonyl-piperazine derivatives as inhibitors of MDA-MB-231 human breast cancer cell proliferation},

journal = {Medicinal Chemistry Research},

year = {2007},

volume = {16},

publisher = {Springer Nature},

month = {aug},

url = {https://doi.org/10.1007/s00044-007-9022-y},

number = {4},

pages = {179--187},

doi = {10.1007/s00044-007-9022-y}

}

MLA

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MLA Copy

Ananda Kumar, C. S., et al. “Synthesis and evaluation of 1-benzhydryl-sulfonyl-piperazine derivatives as inhibitors of MDA-MB-231 human breast cancer cell proliferation.” Medicinal Chemistry Research, vol. 16, no. 4, Aug. 2007, pp. 179-187. https://doi.org/10.1007/s00044-007-9022-y.

Publisher

Springer Nature

Journal

Medicinal Chemistry Research

scimago Q2

wos Q3

SJR

0.470

CiteScore

5.1

Impact factor

3.1

ISSN

10542523 (Print)

15548120 (Electronic)