Medicinal Chemistry Research

, volume 24 , issue 12 , pages 4105-4112

Synthesis of novel mono- and bis-Schiff bases of morpholine derivatives and the investigation of their antimalarial and antiproliferative activities

Aliasghar Jarrahpour ¹

Pouria Shirvani ¹

Hashem Sharghi ¹

Mahdi Aberi ¹

Véronique Sinou ²

Christine Latour ²

Jean Michel Brunel ³

Hide authors affiliations Show authors affiliations: 3 affiliations

Department of Chemistry, College of Sciences, Shiraz University, Shiraz, Iran |

UMR-MD3 Relation hôte-parasites, Physiopathologie & Pharmacologie, Faculté de pharmacie, Aix-Marseille Université, Marseille, France |

Centre de Recherche en Cancérologie de Marseille, Laboratory of Integrative Structural & Chemical Biology (ISCB), UMR CNRS 7258, Faculté de Pharmacie, Aix Marseille Université, Marseille Cedex 05, France |

Publication type: Journal Article

Publication date: 2015-09-07

Springer Nature

Medicinal Chemistry Research

scimago Q2

wos Q3

SJR: 0.470

CiteScore: 5.1

Impact factor: 3.1

ISSN: 10542523, 15548120

DOI: 10.1007/s00044-015-1455-0

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Organic Chemistry

General Pharmacology, Toxicology and Pharmaceutics

Abstract

A series of new Schiff bases of morpholine were prepared by the reaction of 2-hydroxy-3-(morpholinomethyl)benzaldehyde with several mono- and bis-aromatic amines. All these new compounds were characterized by 1H-NMR, 13C-NMR and IR spectroscopy. They were evaluated as antimalarial agents against P. falciparum K14 strain demonstrating moderate to excellent activities. The IC50 of 13 was 2.28 µM. Moreover, derivatives present potent antiproliferative activities against U937 leukemia-derived cell line with EC50 values varying from 3 to 8 µM. Finally, due to its quite low cytotoxicity up to 10 µM against normal fibroblast cells, derivative 13 appeared as a good compromising biologically active product.

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Jarrahpour A. et al. Synthesis of novel mono- and bis-Schiff bases of morpholine derivatives and the investigation of their antimalarial and antiproliferative activities // Medicinal Chemistry Research. 2015. Vol. 24. No. 12. pp. 4105-4112.

GOST all authors (up to 50) Copy

Jarrahpour A., Shirvani P., Sharghi H., Aberi M., Sinou V., Latour C., Brunel J. M. Synthesis of novel mono- and bis-Schiff bases of morpholine derivatives and the investigation of their antimalarial and antiproliferative activities // Medicinal Chemistry Research. 2015. Vol. 24. No. 12. pp. 4105-4112.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1007/s00044-015-1455-0

UR - https://doi.org/10.1007/s00044-015-1455-0

TI - Synthesis of novel mono- and bis-Schiff bases of morpholine derivatives and the investigation of their antimalarial and antiproliferative activities

T2 - Medicinal Chemistry Research

AU - Jarrahpour, Aliasghar

AU - Shirvani, Pouria

AU - Sharghi, Hashem

AU - Aberi, Mahdi

AU - Sinou, Véronique

AU - Latour, Christine

AU - Brunel, Jean Michel

PY - 2015

DA - 2015/09/07

PB - Springer Nature

SP - 4105-4112

IS - 12

VL - 24

SN - 1054-2523

SN - 1554-8120

ER -

BibTex |

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BibTex (up to 50 authors) Copy

@article{2015_Jarrahpour,

author = {Aliasghar Jarrahpour and Pouria Shirvani and Hashem Sharghi and Mahdi Aberi and Véronique Sinou and Christine Latour and Jean Michel Brunel},

title = {Synthesis of novel mono- and bis-Schiff bases of morpholine derivatives and the investigation of their antimalarial and antiproliferative activities},

journal = {Medicinal Chemistry Research},

year = {2015},

volume = {24},

publisher = {Springer Nature},

month = {sep},

url = {https://doi.org/10.1007/s00044-015-1455-0},

number = {12},

pages = {4105--4112},

doi = {10.1007/s00044-015-1455-0}

}

MLA

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MLA Copy

Jarrahpour, Aliasghar, et al. “Synthesis of novel mono- and bis-Schiff bases of morpholine derivatives and the investigation of their antimalarial and antiproliferative activities.” Medicinal Chemistry Research, vol. 24, no. 12, Sep. 2015, pp. 4105-4112. https://doi.org/10.1007/s00044-015-1455-0.

Publisher

Springer Nature

Journal

Medicinal Chemistry Research

scimago Q2

wos Q3

SJR

0.470

CiteScore

5.1

Impact factor

3.1

ISSN

10542523 (Print)

15548120 (Electronic)