Synthesis and evaluation of some novel N-substituted rhodanines for their anticancer activity
Publication type: Journal Article
Publication date: 2016-03-03
scimago Q2
wos Q3
SJR: 0.470
CiteScore: 5.1
Impact factor: 3.1
ISSN: 10542523, 15548120
Organic Chemistry
General Pharmacology, Toxicology and Pharmaceutics
Abstract
Novel N-substituted rhodanines 2a–g were synthesized by conventional and microwave-assisted methods and tested for their anticancer activity. Structure–activity relationship of the synthesized rhodanine 2a–g as antiproliferative agents was investigated. The results revealed that all the seven compounds showed potent antiproliferative activity in a concentration-dependent manner on leukemic cell line K562. Among the tested compounds, 2b was found to be more potent when compared by trypan blue and MTT assay. IC50 values of 2b using trypan blue and MTT assay were found to be 11.1 and 20.3 µg/ml, respectively. A dose-dependent increase in the LDH release was also observed upon treatment with 2a–g. Cell cycle analysis revealed that 2b affects DNA replication and leads to accumulation of cells in G 0 and decline of G 2/M, G 1 and S phases which indicates apoptosis. The selective cytotoxic activity against human chronic myelogenous cell line (K562), via apoptosis, suggests that compound 2b is a promising scaffold for the development of novel anticancer drug.
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Total citations:
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Citations from 2025:
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GOST
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Ali Muhammad S., Ravi S., Thangamani A. Synthesis and evaluation of some novel N-substituted rhodanines for their anticancer activity // Medicinal Chemistry Research. 2016. Vol. 25. No. 5. pp. 994-1004.
GOST all authors (up to 50)
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Ali Muhammad S., Ravi S., Thangamani A. Synthesis and evaluation of some novel N-substituted rhodanines for their anticancer activity // Medicinal Chemistry Research. 2016. Vol. 25. No. 5. pp. 994-1004.
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RIS
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TY - JOUR
DO - 10.1007/s00044-016-1545-7
UR - https://doi.org/10.1007/s00044-016-1545-7
TI - Synthesis and evaluation of some novel N-substituted rhodanines for their anticancer activity
T2 - Medicinal Chemistry Research
AU - Ali Muhammad, Sulaiman
AU - Ravi, Subban
AU - Thangamani, Arumugam
PY - 2016
DA - 2016/03/03
PB - Springer Nature
SP - 994-1004
IS - 5
VL - 25
SN - 1054-2523
SN - 1554-8120
ER -
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BibTex (up to 50 authors)
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@article{2016_Ali Muhammad,
author = {Sulaiman Ali Muhammad and Subban Ravi and Arumugam Thangamani},
title = {Synthesis and evaluation of some novel N-substituted rhodanines for their anticancer activity},
journal = {Medicinal Chemistry Research},
year = {2016},
volume = {25},
publisher = {Springer Nature},
month = {mar},
url = {https://doi.org/10.1007/s00044-016-1545-7},
number = {5},
pages = {994--1004},
doi = {10.1007/s00044-016-1545-7}
}
Cite this
MLA
Copy
Ali Muhammad, Sulaiman, et al. “Synthesis and evaluation of some novel N-substituted rhodanines for their anticancer activity.” Medicinal Chemistry Research, vol. 25, no. 5, Mar. 2016, pp. 994-1004. https://doi.org/10.1007/s00044-016-1545-7.