Medicinal Chemistry Research

, volume 25 , issue 9 , pages 1717-1743

2,4-Disubstituted thiazoles as multitargated bioactive molecules

Preeti Arora ¹

Rakesh Narang ¹

Surendra Kumar Nayak ¹

Sachin Kumar Singh ¹

Vikramjeet Judge ²

Hide authors affiliations Show authors affiliations: 2 affiliations

Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara 144401, India |

Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar 125001, India |

Publication type: Journal Article

Publication date: 2016-07-02

Springer Nature

Medicinal Chemistry Research

scimago Q2

wos Q3

SJR: 0.470

CiteScore: 5.1

Impact factor: 3.1

ISSN: 10542523, 15548120

DOI: 10.1007/s00044-016-1610-2

Copy DOI

Organic Chemistry

General Pharmacology, Toxicology and Pharmaceutics

Abstract

Thiazoles are important heterocyclics exhibiting boundaryless biological activities, such as antibacterial, antifungal, anti-inflammatory, antitumor, antitubercular, antidiabetic, antiviral, and antioxidant. Substituents on a particular position of the thiazole ring affect the biological outcomes to a great extent. Therefore, researchers have synthesized compounds containing the thiazole ring with variable substituents as target structures, and evaluated their biological activities. The present review describes the biological importance of recently developed 2,4-disubstituted thiazole derivatives. Moreover, we have thrown light on various targets of 2,4-disubstituted thiazoles through which they induce biological effects, which will be helpful to those who are working on the design and structure–activity relationship of bioactive molecules.

Found

3 citations

Dotsenko Viktor

DSc in Chemistry, professor

253 publications, 2 819 citations, 2 reviews

h-index: 22

North Caucasus Federal University

Kuban State University

Research interests

Active methylene compounds

Biological activity

Heterocyclic compounds

Malononitrile

Selenoamides

Thioamides

1 citation

Churakov Andrei

PhD in Chemistry

557 publications, 7 120 citations, 14 reviews

h-index: 38

Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences

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GOST |

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GOST Copy

Arora P. et al. 2,4-Disubstituted thiazoles as multitargated bioactive molecules // Medicinal Chemistry Research. 2016. Vol. 25. No. 9. pp. 1717-1743.

GOST all authors (up to 50) Copy

Arora P., Narang R., Nayak S. K., Singh S. K., Judge V. 2,4-Disubstituted thiazoles as multitargated bioactive molecules // Medicinal Chemistry Research. 2016. Vol. 25. No. 9. pp. 1717-1743.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1007/s00044-016-1610-2

UR - https://doi.org/10.1007/s00044-016-1610-2

TI - 2,4-Disubstituted thiazoles as multitargated bioactive molecules

T2 - Medicinal Chemistry Research

AU - Arora, Preeti

AU - Narang, Rakesh

AU - Nayak, Surendra Kumar

AU - Singh, Sachin Kumar

AU - Judge, Vikramjeet

PY - 2016

DA - 2016/07/02

PB - Springer Nature

SP - 1717-1743

IS - 9

VL - 25

SN - 1054-2523

SN - 1554-8120

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2016_Arora,

author = {Preeti Arora and Rakesh Narang and Surendra Kumar Nayak and Sachin Kumar Singh and Vikramjeet Judge},

title = {2,4-Disubstituted thiazoles as multitargated bioactive molecules},

journal = {Medicinal Chemistry Research},

year = {2016},

volume = {25},

publisher = {Springer Nature},

month = {jul},

url = {https://doi.org/10.1007/s00044-016-1610-2},

number = {9},

pages = {1717--1743},

doi = {10.1007/s00044-016-1610-2}

}

MLA

Cite this

MLA Copy

Arora, Preeti, et al. “2,4-Disubstituted thiazoles as multitargated bioactive molecules.” Medicinal Chemistry Research, vol. 25, no. 9, Jul. 2016, pp. 1717-1743. https://doi.org/10.1007/s00044-016-1610-2.

Publisher

Springer Nature

Journal

Medicinal Chemistry Research

scimago Q2

wos Q3

SJR

0.470

CiteScore

5.1

Impact factor

3.1

ISSN

10542523 (Print)

15548120 (Electronic)