Microwave-assisted synthesis and evaluation of their antiproliferative, antimicrobial, activities and DNA Binding studies of (3-Methyl-7H-furo[2,3-f]chromen-2-yl)(aryl)methanones

A series of (3-methyl-7H-furo[2,3-]chromen-2-yl)(aryl)methanones were quickly prepared through easily accessible, short-span progress microwave irradiation and conventional heating methods. The structures of these synthesized compounds were confirmed by IR, NMR (1H, 13C) and mass spectral analysis. Further, the in vitro antiproliferative activities were tested against MCF-7 (human breast adenocarcinoma cells) and C-6 (nerve cells) using the MTT assay. The compounds 5b and 5g a showed better antiproliferative activity than Cisplatin. Additionally, in vitro antibacterial and antifungal activities were carried out against different bacterial and fungal strains. Compounds 5b, 5c and 5g showed a substantial inhibition effect than Ciprofloxacin and Fluconazole standard drugs respectively., UV-Visible and fluorescence measurements were conducted to assess the interaction of the compounds with CT-DNA compounds 5c, 5d, and 5g showed a stronger DNA binding affinity.