Springer Nature
Medicinal Chemistry Research
,  volume 34 ,  issue 4 ,  pages 849-854

A mild and catalyst-free α-benzoyloxylation of tertiary amides

Md Imdadul H. Khan 1
, 
Jiaxin Yang 1
, 
Seong Jong Kim 2
, 
Hoang V. Le 1, 3
1
 
2
 
Natural Products Utilization Research Unit, United States Department of Agriculture, Agricultural Research Service, University, USA | 
3
 
Publication type: Journal Article
Publication date: 2025-02-12
Springer Nature
scimago Q2
wos Q3
SJR: 0.470
CiteScore: 5.1
Impact factor: 3.1
ISSN: 10542523, 15548120
Abstract
An α-C–H oxygenation of amides using Togni reagent II and an umpolung strategy is reported. α-Benzoyloxy amides were prepared in moderate-to-high yields from tertiary amides under mild and catalyst-free reaction conditions. All reagents are commercially available, easy to use, and compatible with various functional groups and rings. α-Benzoyloxy amides could be easily transformed into the corresponding α-hydroxy amides in almost quantitative yields. This transformation has significant potential for the synthesis of important compounds in pharmaceutical and agricultural fields.
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Khan M. I. H. et al. A mild and catalyst-free α-benzoyloxylation of tertiary amides // Medicinal Chemistry Research. 2025. Vol. 34. No. 4. pp. 849-854.
GOST all authors (up to 50) Copy
Khan M. I. H., Yang J., Seong Jong Kim, Le H. V. A mild and catalyst-free α-benzoyloxylation of tertiary amides // Medicinal Chemistry Research. 2025. Vol. 34. No. 4. pp. 849-854.
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TY - JOUR
DO - 10.1007/s00044-025-03381-w
UR - https://link.springer.com/10.1007/s00044-025-03381-w
TI - A mild and catalyst-free α-benzoyloxylation of tertiary amides
T2 - Medicinal Chemistry Research
AU - Khan, Md Imdadul H.
AU - Yang, Jiaxin
AU - Seong Jong Kim
AU - Le, Hoang V.
PY - 2025
DA - 2025/02/12
PB - Springer Nature
SP - 849-854
IS - 4
VL - 34
SN - 1054-2523
SN - 1554-8120
ER -
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BibTex (up to 50 authors) Copy
@article{2025_Khan,
author = {Md Imdadul H. Khan and Jiaxin Yang and Seong Jong Kim and Hoang V. Le},
title = {A mild and catalyst-free α-benzoyloxylation of tertiary amides},
journal = {Medicinal Chemistry Research},
year = {2025},
volume = {34},
publisher = {Springer Nature},
month = {feb},
url = {https://link.springer.com/10.1007/s00044-025-03381-w},
number = {4},
pages = {849--854},
doi = {10.1007/s00044-025-03381-w}
}
MLA
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Khan, Md Imdadul H., et al. “A mild and catalyst-free α-benzoyloxylation of tertiary amides.” Medicinal Chemistry Research, vol. 34, no. 4, Feb. 2025, pp. 849-854. https://link.springer.com/10.1007/s00044-025-03381-w.