Applied Microbiology and Biotechnology

, том 48 , издание 2 , страницы 174-176

Bioconversion of 2-cyanopyrazine to 5-hydroxypyrazine-2-carboxylic acid with Agrobacterium sp. DSM 6336

Тип публикации: Journal Article

Дата публикации: 1997-08-25

Springer Nature

Applied Microbiology and Biotechnology

SCImago Q1

WOS Q2

БС1

SJR: 1.008

CiteScore: 9

Impact factor: 4.7

ISSN: 01757598, 14320614

DOI: 10.1007/s002530051034

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General Medicine

Applied Microbiology and Biotechnology

Biotechnology

Краткое описание

5-Hydroxypyrazine-2-carboxylic acid, a versatile building block for the synthesis of new antituberculous agents, was prepared by whole-cell biotransformation from 2-cyanopyrazine via pyrazinecarboxylic acid using Agrobacterium sp. DSM 6336. By developing a fermentation process for this two-enzyme-step bioconversion, a product concentration of 286 mM (40 g/l) was obtained. After the isolation method had been optimized the total yield was 80%.

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Wieser M., Heinzmann K., KIENER A. Bioconversion of 2-cyanopyrazine to 5-hydroxypyrazine-2-carboxylic acid with Agrobacterium sp. DSM 6336 // Applied Microbiology and Biotechnology. 1997. Vol. 48. No. 2. pp. 174-176.

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TY - JOUR

DO - 10.1007/s002530051034

UR - https://doi.org/10.1007/s002530051034

TI - Bioconversion of 2-cyanopyrazine to 5-hydroxypyrazine-2-carboxylic acid with Agrobacterium sp. DSM 6336

T2 - Applied Microbiology and Biotechnology

AU - Wieser, M

AU - Heinzmann, K

AU - KIENER, A.

PY - 1997

DA - 1997/08/25

PB - Springer Nature

SP - 174-176

IS - 2

VL - 48

SN - 0175-7598

SN - 1432-0614

ER -

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@article{1997_Wieser,

author = {M Wieser and K Heinzmann and A. KIENER},

title = {Bioconversion of 2-cyanopyrazine to 5-hydroxypyrazine-2-carboxylic acid with Agrobacterium sp. DSM 6336},

journal = {Applied Microbiology and Biotechnology},

year = {1997},

volume = {48},

publisher = {Springer Nature},

month = {aug},

url = {https://doi.org/10.1007/s002530051034},

number = {2},

pages = {174--176},

doi = {10.1007/s002530051034}

}

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Wieser, M., et al. “Bioconversion of 2-cyanopyrazine to 5-hydroxypyrazine-2-carboxylic acid with Agrobacterium sp. DSM 6336.” Applied Microbiology and Biotechnology, vol. 48, no. 2, Aug. 1997, pp. 174-176. https://doi.org/10.1007/s002530051034.

Издатель

Springer Nature

Журнал

Applied Microbiology and Biotechnology

SCImago Q1

WOS Q2

БС1

SJR

1.008

CiteScore

Impact factor

4.7

ISSN

01757598 (Print)

14320614 (Electronic)

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