Immune response as a possible mechanism of long-lasting disease control in spontaneous remission of MLL/AF9-positive acute myeloid leukemia
Claudia Müller Schmah
1
,
Leticia Solari
1
,
Roland Weis
1
,
Dietmar Pfeifer
1
,
Carmen Scheibenbogen
2
,
Martin Trepel
1, 3
,
Annette M May
4
,
Rupert Engelhardt
1
,
Michael Lübbert
1
2
Institute for Medical Immunology, Berlin, Germany
|
3
Publication type: Journal Article
Publication date: 2011-09-29
scimago Q2
wos Q2
SJR: 0.862
CiteScore: 4.0
Impact factor: 2.4
ISSN: 09395555, 14320584
PubMed ID:
21959947
General Medicine
Hematology
Abstract
Spontaneous complete remission (CR) is a rare, poorly understood phenomenon in acute myeloid leukemia (AML). We describe the 10-year follow-up of a patient with MLL-AF9-positive AML (Müller et al. Eur J Haematol 73:62–66, 2004), including ex vivo antileukemic immune responses which may contribute to the long-lasting spontaneous CR (tantamount to cure). We could demonstrate strong in vitro cytotoxic activity mediated by the patient’s serum (cryopreserved at diagnosis 2001) against myeloid cell lines. We also addressed cellular cytotoxic activity against myeloid leukemia cells. When the patient’s natural killer (NK) cells (obtained in 2007) were tested against the K562 cell line, upregulation of CD107 occurred, implying that long-term CR in this patient could be due to NK cell-mediated disease control.
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MLA
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GOST
Copy
Müller Schmah C. et al. Immune response as a possible mechanism of long-lasting disease control in spontaneous remission of MLL/AF9-positive acute myeloid leukemia // Annals of Hematology. 2011. Vol. 91. No. 1. pp. 27-32.
GOST all authors (up to 50)
Copy
Müller Schmah C., Solari L., Weis R., Pfeifer D., Scheibenbogen C., Trepel M., May A. M., Engelhardt R., Lübbert M. Immune response as a possible mechanism of long-lasting disease control in spontaneous remission of MLL/AF9-positive acute myeloid leukemia // Annals of Hematology. 2011. Vol. 91. No. 1. pp. 27-32.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1007/s00277-011-1332-y
UR - https://doi.org/10.1007/s00277-011-1332-y
TI - Immune response as a possible mechanism of long-lasting disease control in spontaneous remission of MLL/AF9-positive acute myeloid leukemia
T2 - Annals of Hematology
AU - Müller Schmah, Claudia
AU - Solari, Leticia
AU - Weis, Roland
AU - Pfeifer, Dietmar
AU - Scheibenbogen, Carmen
AU - Trepel, Martin
AU - May, Annette M
AU - Engelhardt, Rupert
AU - Lübbert, Michael
PY - 2011
DA - 2011/09/29
PB - Springer Nature
SP - 27-32
IS - 1
VL - 91
PMID - 21959947
SN - 0939-5555
SN - 1432-0584
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2011_Müller Schmah,
author = {Claudia Müller Schmah and Leticia Solari and Roland Weis and Dietmar Pfeifer and Carmen Scheibenbogen and Martin Trepel and Annette M May and Rupert Engelhardt and Michael Lübbert},
title = {Immune response as a possible mechanism of long-lasting disease control in spontaneous remission of MLL/AF9-positive acute myeloid leukemia},
journal = {Annals of Hematology},
year = {2011},
volume = {91},
publisher = {Springer Nature},
month = {sep},
url = {https://doi.org/10.1007/s00277-011-1332-y},
number = {1},
pages = {27--32},
doi = {10.1007/s00277-011-1332-y}
}
Cite this
MLA
Copy
Müller Schmah, Claudia, et al. “Immune response as a possible mechanism of long-lasting disease control in spontaneous remission of MLL/AF9-positive acute myeloid leukemia.” Annals of Hematology, vol. 91, no. 1, Sep. 2011, pp. 27-32. https://doi.org/10.1007/s00277-011-1332-y.