Archives of Virology

, volume 161 , issue 5 , pages 1189-1198

The influence of host factors and sequence variability of the p7 region on the response to pegylated interferon/ribavirin therapy for chronic hepatitis C genotype 1b in patients from Serbia

Snezana Jovanovic Cupic ¹

Sanja Glisic ²

Maja Stanojević ³

Darko Nozic ⁴

Nina Petrović ¹

Vesna Mandušić ¹

Milena Krajnović ¹

Hide authors affiliations Show authors affiliations: 4 affiliations

Laboratory for Radiobiology and Molecular Genetics, Institute of Nuclear Sciences, Vinca, University of Belgrade, Belgrade, Serbia |

Center for Multidisciplinary Research, Institute of Nuclear Sciences, Vinca, University of Belgrade, Belgrade, Serbia |

Institute of Microbiology and Immunology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia |

⁴

Clinics of Infectious and Tropical Diseases, Military Medical Academy, Belgrade, Serbia |

Publication type: Journal Article

Publication date: 2016-02-10

Springer Nature

Archives of Virology

scimago Q2

wos Q3

SJR: 0.671

CiteScore: 5.3

Impact factor: 2.5

ISSN: 03048608, 14328798

DOI: 10.1007/s00705-016-2777-z

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PubMed ID: 26860912

General Medicine

Virology

Abstract

The goal of this study was to identify host and viral factors affecting the response to pegylated interferon/ribavirin (PEG-IFN/RBV) treatment in patients with chronic hepatitis C genotype 1b. Baseline characteristics of the patients and sequences within the p7 region were analyzed in pre-treatment serum samples from 53 individuals with chronic hepatitis C genotype 1b and related to the outcome of therapy. We found a significant correlation between age and response to therapy (p < 0.001). Furthermore, the pre-treatment viral load was closely associated with the stage of liver fibrosis (p < 0.001). The presence of fewer than 4 mutations and age above 40 were significantly associated with non-response (NR) (p < 0.001). Our findings may be useful for estimating the likelihood of achieving a sustained virologic response (SVR) in patients who are chronically infected with hepatitis C virus genotype 1b.

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Jovanovic Cupic S. et al. The influence of host factors and sequence variability of the p7 region on the response to pegylated interferon/ribavirin therapy for chronic hepatitis C genotype 1b in patients from Serbia // Archives of Virology. 2016. Vol. 161. No. 5. pp. 1189-1198.

GOST all authors (up to 50) Copy

Jovanovic Cupic S., Glisic S., Stanojević M., Nozic D., Petrović N., Mandušić V., Krajnović M. The influence of host factors and sequence variability of the p7 region on the response to pegylated interferon/ribavirin therapy for chronic hepatitis C genotype 1b in patients from Serbia // Archives of Virology. 2016. Vol. 161. No. 5. pp. 1189-1198.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1007/s00705-016-2777-z

UR - https://doi.org/10.1007/s00705-016-2777-z

TI - The influence of host factors and sequence variability of the p7 region on the response to pegylated interferon/ribavirin therapy for chronic hepatitis C genotype 1b in patients from Serbia

T2 - Archives of Virology

AU - Jovanovic Cupic, Snezana

AU - Glisic, Sanja

AU - Stanojević, Maja

AU - Nozic, Darko

AU - Petrović, Nina

AU - Mandušić, Vesna

AU - Krajnović, Milena

PY - 2016

DA - 2016/02/10

PB - Springer Nature

SP - 1189-1198

IS - 5

VL - 161

PMID - 26860912

SN - 0304-8608

SN - 1432-8798

ER -

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@article{2016_Jovanovic Cupic,

author = {Snezana Jovanovic Cupic and Sanja Glisic and Maja Stanojević and Darko Nozic and Nina Petrović and Vesna Mandušić and Milena Krajnović},

title = {The influence of host factors and sequence variability of the p7 region on the response to pegylated interferon/ribavirin therapy for chronic hepatitis C genotype 1b in patients from Serbia},

journal = {Archives of Virology},

year = {2016},

volume = {161},

publisher = {Springer Nature},

month = {feb},

url = {https://doi.org/10.1007/s00705-016-2777-z},

number = {5},

pages = {1189--1198},

doi = {10.1007/s00705-016-2777-z}

}

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Jovanovic Cupic, Snezana, et al. “The influence of host factors and sequence variability of the p7 region on the response to pegylated interferon/ribavirin therapy for chronic hepatitis C genotype 1b in patients from Serbia.” Archives of Virology, vol. 161, no. 5, Feb. 2016, pp. 1189-1198. https://doi.org/10.1007/s00705-016-2777-z.