Synthesis and lipophilicity evaluation of some novel indole-containing pseudopeptides
Nahid S Alavijeh
1
,
Sorour Ramezanpour
1
,
Mohammad S. Alavijeh
2
,
Saeed Balalaie
1
,
Frank Rominger
3
,
Anil Misra
2
,
Hamid Reza Bijanzadeh
1
2
Pharmidex Pharmaceutical Services Ltd., London, UK
|
Publication type: Journal Article
Publication date: 2013-11-05
scimago Q3
wos Q3
SJR: 0.321
CiteScore: 3.4
Impact factor: 1.9
ISSN: 00269247, 14344475
General Chemistry
Abstract
An efficient synthesis of indole-containing pseudopeptides via an Ugi four-component reaction among indolecarboxylic acids, aromatic aldehydes, primary amines, and isocyanides in methanol is described. The lipophilicity of the synthesized compounds was determined using the n-octanol/PBS shake-flask procedure. The lipophilicity studies showed that most of the compounds possess the optimal range of lipophilicity for oral absorption, cell membrane penetration, and blood-brain barrier permeation.
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Alavijeh N. S. et al. Synthesis and lipophilicity evaluation of some novel indole-containing pseudopeptides // Monatshefte fur Chemie. 2013. Vol. 145. No. 2. pp. 349-356.
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Alavijeh N. S., Ramezanpour S., Alavijeh M. S., Balalaie S., Rominger F., Misra A., Bijanzadeh H. R. Synthesis and lipophilicity evaluation of some novel indole-containing pseudopeptides // Monatshefte fur Chemie. 2013. Vol. 145. No. 2. pp. 349-356.
Cite this
RIS
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TY - JOUR
DO - 10.1007/s00706-013-1098-0
UR - https://doi.org/10.1007/s00706-013-1098-0
TI - Synthesis and lipophilicity evaluation of some novel indole-containing pseudopeptides
T2 - Monatshefte fur Chemie
AU - Alavijeh, Nahid S
AU - Ramezanpour, Sorour
AU - Alavijeh, Mohammad S.
AU - Balalaie, Saeed
AU - Rominger, Frank
AU - Misra, Anil
AU - Bijanzadeh, Hamid Reza
PY - 2013
DA - 2013/11/05
PB - Springer Nature
SP - 349-356
IS - 2
VL - 145
SN - 0026-9247
SN - 1434-4475
ER -
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BibTex (up to 50 authors)
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@article{2013_Alavijeh,
author = {Nahid S Alavijeh and Sorour Ramezanpour and Mohammad S. Alavijeh and Saeed Balalaie and Frank Rominger and Anil Misra and Hamid Reza Bijanzadeh},
title = {Synthesis and lipophilicity evaluation of some novel indole-containing pseudopeptides},
journal = {Monatshefte fur Chemie},
year = {2013},
volume = {145},
publisher = {Springer Nature},
month = {nov},
url = {https://doi.org/10.1007/s00706-013-1098-0},
number = {2},
pages = {349--356},
doi = {10.1007/s00706-013-1098-0}
}
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MLA
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Alavijeh, Nahid S., et al. “Synthesis and lipophilicity evaluation of some novel indole-containing pseudopeptides.” Monatshefte fur Chemie, vol. 145, no. 2, Nov. 2013, pp. 349-356. https://doi.org/10.1007/s00706-013-1098-0.