Densitometric simultaneous estimation of combination of empagliflozin, linagliptin and metformin hydrochloride used in the treatment of type 2 diabetes mellitus
1
Department of Pharmaceutical Chemistry and Analysis, Indukaka Ipcowala College of Pharmacy, Vitthal Udyognagar, India
|
2
Babaria Institute of Pharmacy, Vadodara, India
|
Publication type: Journal Article
Publication date: 2020-04-01
scimago Q3
wos Q4
SJR: 0.250
CiteScore: 1.9
Impact factor: 1.1
ISSN: 09334173, 17890993
Biochemistry
Clinical Biochemistry
Analytical Chemistry
Abstract
A sensitive, accurate, precise, and robust high-performance thin-layer chromatography (HPTLC) method has been developed for the simultaneous quantification of empagliflozin, linagliptin, and metformin HCl in bulk and synthetic mixture. The method applied HPTLC aluminum plates pre-coated with silica gel 60 F254 as the stationary phase along with n-butanol:water:glacial acetic acid (6:3:1, v/v) as the mobile phase. The Rf values of empagliflozin, linagliptin, and metformin HCl were found to be 0.73, 0.52, and 0.33, respectively. Densitometric analysis was carried out in the absorbance mode at 223 nm. The method was obtained linear in the range of 0.1–0.7 μg/band for empagliflozin, 0.05–0.35 μg/band for linagliptin, and 10–70 μg/band for metformin HCl, respectively. From synthetic mixture, the percentage (%) amounts of all three drugs were found to be more than 98% by the proposed HPTLC method. The method was validated as per the International Conference on Harmonisation (ICH) guideline Q2(R1).
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
1
2
|
|
|
Research Journal of Pharmacy and Technology
2 publications, 10.53%
|
|
|
Royal Society Open Science
1 publication, 5.26%
|
|
|
Journal of the Electrochemical Society
1 publication, 5.26%
|
|
|
Separations
1 publication, 5.26%
|
|
|
Future Journal of Pharmaceutical Sciences
1 publication, 5.26%
|
|
|
Arabian Journal of Chemistry
1 publication, 5.26%
|
|
|
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
1 publication, 5.26%
|
|
|
Optik
1 publication, 5.26%
|
|
|
Journal of Liquid Chromatography and Related Technologies
1 publication, 5.26%
|
|
|
European Journal of Chemistry
1 publication, 5.26%
|
|
|
Biomedical Chromatography
1 publication, 5.26%
|
|
|
Sustainable Chemistry and Pharmacy
1 publication, 5.26%
|
|
|
Journal of Separation Science
1 publication, 5.26%
|
|
|
BMC Chemistry
1 publication, 5.26%
|
|
|
Luminescence
1 publication, 5.26%
|
|
|
Accreditation and Quality Assurance
1 publication, 5.26%
|
|
|
Bioanalysis
1 publication, 5.26%
|
|
|
Discover Chemistry
1 publication, 5.26%
|
|
|
1
2
|
Publishers
|
1
2
3
4
|
|
|
Springer Nature
4 publications, 21.05%
|
|
|
Elsevier
3 publications, 15.79%
|
|
|
Wiley
3 publications, 15.79%
|
|
|
Taylor & Francis
2 publications, 10.53%
|
|
|
A and V Publications
2 publications, 10.53%
|
|
|
The Royal Society
1 publication, 5.26%
|
|
|
The Electrochemical Society
1 publication, 5.26%
|
|
|
MDPI
1 publication, 5.26%
|
|
|
King Saud University
1 publication, 5.26%
|
|
|
European Journal of Chemistry
1 publication, 5.26%
|
|
|
1
2
3
4
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
19
Total citations:
19
Citations from 2024:
5
(26.32%)
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Patel I. M. et al. Densitometric simultaneous estimation of combination of empagliflozin, linagliptin and metformin hydrochloride used in the treatment of type 2 diabetes mellitus // Journal of Planar Chromatography - Modern TLC. 2020. Vol. 33. No. 2. pp. 109-118.
GOST all authors (up to 50)
Copy
Patel I. M., Chhalotiya U. K., Jani H. D., Kansara D., Shah D. A. Densitometric simultaneous estimation of combination of empagliflozin, linagliptin and metformin hydrochloride used in the treatment of type 2 diabetes mellitus // Journal of Planar Chromatography - Modern TLC. 2020. Vol. 33. No. 2. pp. 109-118.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1007/s00764-020-00026-z
UR - https://doi.org/10.1007/s00764-020-00026-z
TI - Densitometric simultaneous estimation of combination of empagliflozin, linagliptin and metformin hydrochloride used in the treatment of type 2 diabetes mellitus
T2 - Journal of Planar Chromatography - Modern TLC
AU - Patel, Ishita M
AU - Chhalotiya, Usmangani K
AU - Jani, Harsha D
AU - Kansara, Devansh
AU - Shah, Dimal A
PY - 2020
DA - 2020/04/01
PB - Akademiai Kiado
SP - 109-118
IS - 2
VL - 33
SN - 0933-4173
SN - 1789-0993
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2020_Patel,
author = {Ishita M Patel and Usmangani K Chhalotiya and Harsha D Jani and Devansh Kansara and Dimal A Shah},
title = {Densitometric simultaneous estimation of combination of empagliflozin, linagliptin and metformin hydrochloride used in the treatment of type 2 diabetes mellitus},
journal = {Journal of Planar Chromatography - Modern TLC},
year = {2020},
volume = {33},
publisher = {Akademiai Kiado},
month = {apr},
url = {https://doi.org/10.1007/s00764-020-00026-z},
number = {2},
pages = {109--118},
doi = {10.1007/s00764-020-00026-z}
}
Cite this
MLA
Copy
Patel, Ishita M., et al. “Densitometric simultaneous estimation of combination of empagliflozin, linagliptin and metformin hydrochloride used in the treatment of type 2 diabetes mellitus.” Journal of Planar Chromatography - Modern TLC, vol. 33, no. 2, Apr. 2020, pp. 109-118. https://doi.org/10.1007/s00764-020-00026-z.