Comparative Study of Wound-Healing Activity of Dihydroquercetin Pseudopolymorphic Modifications
R P Terekhov
1
,
I A Selivanova
1
,
M N Anurova
2
,
A K Zhevlakova
1
,
I D Nikitin
1
,
Zh Cong
3
,
S. Ma
3
,
F. Yang
3
,
Z. Dong
3
,
Y. Liao
3
Publication type: Journal Article
Publication date: 2021-02-01
scimago Q3
wos Q4
SJR: 0.277
CiteScore: 1.5
Impact factor: 0.6
ISSN: 00074888, 15738221, 03659615, 24131008
PubMed ID:
33713223
General Biochemistry, Genetics and Molecular Biology
General Medicine
Abstract
Wound-healing activity of the crystalline form of dihydroquercetin and its microtubular pseudopolymorphic modification obtained by crystal engineering was compared using the rat model of IIIA degree burn. The rate of wound healing in the group treated with microtubular pseudopolymorphic modification of dihydroquercetin was 4.8±0.1%, which was higher by 11.6% than in the group treated with crystalline form (4.3±0.1%). Bioavailability analysis on MDCK cell culture showed that the apparent permeability coefficient of microtubular pseudopolymorphic modification was higher than that of crystalline form by 31.1% (19.4±0.2×10–4 and 14.8±0.3×10–4 cm/sec, respectively). It was proven that the use of crystal engineering improved the biopharmaceutical parameters of dihydroquercetin and increased its pharmacological efficiency.
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12
Total citations:
12
Citations from 2024:
5
(41%)
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GOST
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Terekhov R. P. et al. Comparative Study of Wound-Healing Activity of Dihydroquercetin Pseudopolymorphic Modifications // Bulletin of Experimental Biology and Medicine. 2021. Vol. 170. No. 4. pp. 444-447.
GOST all authors (up to 50)
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Terekhov R. P., Selivanova I. A., Anurova M. N., Zhevlakova A. K., Nikitin I. D., Cong Z., Ma S., Yang F., Dong Z., Liao Y. Comparative Study of Wound-Healing Activity of Dihydroquercetin Pseudopolymorphic Modifications // Bulletin of Experimental Biology and Medicine. 2021. Vol. 170. No. 4. pp. 444-447.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1007/s10517-021-05083-w
UR - https://doi.org/10.1007/s10517-021-05083-w
TI - Comparative Study of Wound-Healing Activity of Dihydroquercetin Pseudopolymorphic Modifications
T2 - Bulletin of Experimental Biology and Medicine
AU - Terekhov, R P
AU - Selivanova, I A
AU - Anurova, M N
AU - Zhevlakova, A K
AU - Nikitin, I D
AU - Cong, Zh
AU - Ma, S.
AU - Yang, F.
AU - Dong, Z.
AU - Liao, Y.
PY - 2021
DA - 2021/02/01
PB - Springer Nature
SP - 444-447
IS - 4
VL - 170
PMID - 33713223
SN - 0007-4888
SN - 1573-8221
SN - 0365-9615
SN - 2413-1008
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2021_Terekhov,
author = {R P Terekhov and I A Selivanova and M N Anurova and A K Zhevlakova and I D Nikitin and Zh Cong and S. Ma and F. Yang and Z. Dong and Y. Liao},
title = {Comparative Study of Wound-Healing Activity of Dihydroquercetin Pseudopolymorphic Modifications},
journal = {Bulletin of Experimental Biology and Medicine},
year = {2021},
volume = {170},
publisher = {Springer Nature},
month = {feb},
url = {https://doi.org/10.1007/s10517-021-05083-w},
number = {4},
pages = {444--447},
doi = {10.1007/s10517-021-05083-w}
}
Cite this
MLA
Copy
Terekhov, R. P., et al. “Comparative Study of Wound-Healing Activity of Dihydroquercetin Pseudopolymorphic Modifications.” Bulletin of Experimental Biology and Medicine, vol. 170, no. 4, Feb. 2021, pp. 444-447. https://doi.org/10.1007/s10517-021-05083-w.