Bulletin of Experimental Biology and Medicine, volume 170, issue 4, pages 444-447
Comparative Study of Wound-Healing Activity of Dihydroquercetin Pseudopolymorphic Modifications
Terekhov R P
1
,
Selivanova I A
1
,
Anurova M N
2
,
Zhevlakova A K
1
,
Nikitin I D
1
,
Cong Zh
3
,
Ma S.
3
,
Yang F.
3
,
Dong Z.
3
,
Liao Y.
3
Publication type: Journal Article
Publication date: 2021-02-01
Quartile SCImago
Q3
Quartile WOS
Q4
Impact factor: 0.7
ISSN: 00074888, 15738221, 03659615, 24131008
General Biochemistry, Genetics and Molecular Biology
General Medicine
Abstract
Wound-healing activity of the crystalline form of dihydroquercetin and its microtubular pseudopolymorphic modification obtained by crystal engineering was compared using the rat model of IIIA degree burn. The rate of wound healing in the group treated with microtubular pseudopolymorphic modification of dihydroquercetin was 4.8±0.1%, which was higher by 11.6% than in the group treated with crystalline form (4.3±0.1%). Bioavailability analysis on MDCK cell culture showed that the apparent permeability coefficient of microtubular pseudopolymorphic modification was higher than that of crystalline form by 31.1% (19.4±0.2×10–4 and 14.8±0.3×10–4 cm/sec, respectively). It was proven that the use of crystal engineering improved the biopharmaceutical parameters of dihydroquercetin and increased its pharmacological efficiency.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Terekhov R. P. et al. Comparative Study of Wound-Healing Activity of Dihydroquercetin Pseudopolymorphic Modifications // Bulletin of Experimental Biology and Medicine. 2021. Vol. 170. No. 4. pp. 444-447.
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Terekhov R. P., Selivanova I. A., Anurova M. N., Zhevlakova A. K., Nikitin I. D., Cong Z., Ma S., Yang F., Dong Z., Liao Y. Comparative Study of Wound-Healing Activity of Dihydroquercetin Pseudopolymorphic Modifications // Bulletin of Experimental Biology and Medicine. 2021. Vol. 170. No. 4. pp. 444-447.
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TY - JOUR
DO - 10.1007/s10517-021-05083-w
UR - https://doi.org/10.1007%2Fs10517-021-05083-w
TI - Comparative Study of Wound-Healing Activity of Dihydroquercetin Pseudopolymorphic Modifications
T2 - Bulletin of Experimental Biology and Medicine
AU - Terekhov, R P
AU - Selivanova, I A
AU - Anurova, M N
AU - Zhevlakova, A K
AU - Nikitin, I D
AU - Cong, Zh
AU - Ma, S.
AU - Yang, F.
AU - Dong, Z.
AU - Liao, Y.
PY - 2021
DA - 2021/02/01 00:00:00
PB - Springer Nature
SP - 444-447
IS - 4
VL - 170
SN - 0007-4888
SN - 1573-8221
SN - 0365-9615
SN - 2413-1008
ER -
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@article{2021_Terekhov,
author = {R P Terekhov and I A Selivanova and M N Anurova and A K Zhevlakova and I D Nikitin and Zh Cong and S. Ma and F. Yang and Z. Dong and Y. Liao},
title = {Comparative Study of Wound-Healing Activity of Dihydroquercetin Pseudopolymorphic Modifications},
journal = {Bulletin of Experimental Biology and Medicine},
year = {2021},
volume = {170},
publisher = {Springer Nature},
month = {feb},
url = {https://doi.org/10.1007%2Fs10517-021-05083-w},
number = {4},
pages = {444--447},
doi = {10.1007/s10517-021-05083-w}
}
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Terekhov, R. P., et al. “Comparative Study of Wound-Healing Activity of Dihydroquercetin Pseudopolymorphic Modifications.” Bulletin of Experimental Biology and Medicine, vol. 170, no. 4, Feb. 2021, pp. 444-447. https://doi.org/10.1007%2Fs10517-021-05083-w.