Springer Nature
Bulletin of Experimental Biology and Medicine
,  volume 178 ,  issue 4 ,  pages 410-414

Activation of the Complement System and Changes in the Content of Modified Lipoproteins in Antiorthostatic Hypokinesia in Humans and Mice

Publication type: Journal Article
Publication date: 2025-02-01
Springer Nature
scimago Q3
wos Q4
SJR: 0.277
CiteScore: 1.5
Impact factor: 0.6
ISSN: 00074888, 15738221, 03659615, 24131008
Abstract
The correlation between the total activity of the complement system (TACS) and the content of modified LDL (mLDL) in blood serum when modeling microgravity in Earth conditions was evaluated. Healthy volunteers were placed in a state of antiorthostatic hypokinesia for 21 days. Microgravity in ICR mice was modeled by tail suspension for 14 days. TACS, activity of the alternative pathway (in humans), and the content of mLDL in serum from volunteers and mice were measured by turbidimetry. On day 7 of antiorthostatic hypokinesia, volunteers had a significant increase in TACS, which persisted until day 21. The content of mLDL in blood serum increased significantly on day 7. In experiments with mice, TACS increased significantly on day 14, and mLDL content decreased significantly. The limitation of mobility, which is an integral part of microgravity modeling, causes an increase in the overall hemolytic activity of the complement system in both humans and laboratory animals, indicating a response to significant physiological stress.
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Alchinova I. B. et al. Activation of the Complement System and Changes in the Content of Modified Lipoproteins in Antiorthostatic Hypokinesia in Humans and Mice // Bulletin of Experimental Biology and Medicine. 2025. Vol. 178. No. 4. pp. 410-414.
GOST all authors (up to 50) Copy
Alchinova I. B., Shoibonov B. B., Puchkova A. A., Karganov M. Yu. Activation of the Complement System and Changes in the Content of Modified Lipoproteins in Antiorthostatic Hypokinesia in Humans and Mice // Bulletin of Experimental Biology and Medicine. 2025. Vol. 178. No. 4. pp. 410-414.
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TY - JOUR
DO - 10.1007/s10517-025-06346-6
UR - https://link.springer.com/10.1007/s10517-025-06346-6
TI - Activation of the Complement System and Changes in the Content of Modified Lipoproteins in Antiorthostatic Hypokinesia in Humans and Mice
T2 - Bulletin of Experimental Biology and Medicine
AU - Alchinova, I B
AU - Shoibonov, B B
AU - Puchkova, A A
AU - Karganov, M Yu
PY - 2025
DA - 2025/02/01
PB - Springer Nature
SP - 410-414
IS - 4
VL - 178
SN - 0007-4888
SN - 1573-8221
SN - 0365-9615
SN - 2413-1008
ER -
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@article{2025_Alchinova,
author = {I B Alchinova and B B Shoibonov and A A Puchkova and M Yu Karganov},
title = {Activation of the Complement System and Changes in the Content of Modified Lipoproteins in Antiorthostatic Hypokinesia in Humans and Mice},
journal = {Bulletin of Experimental Biology and Medicine},
year = {2025},
volume = {178},
publisher = {Springer Nature},
month = {feb},
url = {https://link.springer.com/10.1007/s10517-025-06346-6},
number = {4},
pages = {410--414},
doi = {10.1007/s10517-025-06346-6}
}
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Alchinova, I. B., et al. “Activation of the Complement System and Changes in the Content of Modified Lipoproteins in Antiorthostatic Hypokinesia in Humans and Mice.” Bulletin of Experimental Biology and Medicine, vol. 178, no. 4, Feb. 2025, pp. 410-414. https://link.springer.com/10.1007/s10517-025-06346-6.