Synthesis and antiviral activity of nonannulated tetrazolylpyrimidines
Vladimir А Ostrovskii
1
,
Gevorg G Danagulyan
2, 3
,
Olga M. Nesterova
1
,
Yulia N Pavlyukova
1
,
Vladimir V Tolstyakov
1
,
Olga S Zarubina
1
,
Pavel А Slepukhin
4
,
Yana L Esaulkova
5
,
Anna А Muryleva
5
,
Vladimir V. Zarubaev
5
,
Rostislav E. Trifonov
1
Publication type: Journal Article
Publication date: 2021-04-01
scimago Q4
wos Q4
SJR: 0.243
CiteScore: 2.7
Impact factor: 1.0
ISSN: 00093122, 15738353
PubMed ID:
34007083
Organic Chemistry
Abstract
Nonannulated tetrazolylpyrimidines in the structure of which the heterocyclic fragments are separated by hydrazinocarbonylmethyl, methylpyrazolyl groups or a sulfur atom were synthesized. Some of these compounds showed moderate in vitro activity against H1N1 subtype of influenza A virus. The selectivity index of the anti-influenza action of {5-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]-1H-tetrazol-1-yl}acetic acid, which has very low cytotoxicity, was twice as high as the selectivity index of the reference drug rimantadine.
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Total citations:
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GOST
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Ostrovskii V. А. et al. Synthesis and antiviral activity of nonannulated tetrazolylpyrimidines // Chemistry of Heterocyclic Compounds. 2021. Vol. 57. No. 4. pp. 448-454.
GOST all authors (up to 50)
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Ostrovskii V. А., Danagulyan G. G., Nesterova O. M., Pavlyukova Y. N., Tolstyakov V. V., Zarubina O. S., Slepukhin P. А., Esaulkova Y. L., Muryleva A. А., Zarubaev V. V., Trifonov R. E. Synthesis and antiviral activity of nonannulated tetrazolylpyrimidines // Chemistry of Heterocyclic Compounds. 2021. Vol. 57. No. 4. pp. 448-454.
Cite this
RIS
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TY - JOUR
DO - 10.1007/s10593-021-02922-6
UR - https://doi.org/10.1007/s10593-021-02922-6
TI - Synthesis and antiviral activity of nonannulated tetrazolylpyrimidines
T2 - Chemistry of Heterocyclic Compounds
AU - Ostrovskii, Vladimir А
AU - Danagulyan, Gevorg G
AU - Nesterova, Olga M.
AU - Pavlyukova, Yulia N
AU - Tolstyakov, Vladimir V
AU - Zarubina, Olga S
AU - Slepukhin, Pavel А
AU - Esaulkova, Yana L
AU - Muryleva, Anna А
AU - Zarubaev, Vladimir V.
AU - Trifonov, Rostislav E.
PY - 2021
DA - 2021/04/01
PB - Springer Nature
SP - 448-454
IS - 4
VL - 57
PMID - 34007083
SN - 0009-3122
SN - 1573-8353
ER -
Cite this
BibTex (up to 50 authors)
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@article{2021_Ostrovskii,
author = {Vladimir А Ostrovskii and Gevorg G Danagulyan and Olga M. Nesterova and Yulia N Pavlyukova and Vladimir V Tolstyakov and Olga S Zarubina and Pavel А Slepukhin and Yana L Esaulkova and Anna А Muryleva and Vladimir V. Zarubaev and Rostislav E. Trifonov},
title = {Synthesis and antiviral activity of nonannulated tetrazolylpyrimidines},
journal = {Chemistry of Heterocyclic Compounds},
year = {2021},
volume = {57},
publisher = {Springer Nature},
month = {apr},
url = {https://doi.org/10.1007/s10593-021-02922-6},
number = {4},
pages = {448--454},
doi = {10.1007/s10593-021-02922-6}
}
Cite this
MLA
Copy
Ostrovskii, Vladimir А., et al. “Synthesis and antiviral activity of nonannulated tetrazolylpyrimidines.” Chemistry of Heterocyclic Compounds, vol. 57, no. 4, Apr. 2021, pp. 448-454. https://doi.org/10.1007/s10593-021-02922-6.