Springer Nature
Chemistry of Heterocyclic Compounds
,  том 60 ,  издание 5-6 ,  страницы 245-250

The synthesis of 1-oxa-9-azaspiro[5.5]undecane derivatives and optimization of antituberculosis activity thereof

Тип публикации: Journal Article
Дата публикации: 2024-06-01
Springer Nature
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SJR: 0.243
CiteScore: 2.7
Impact factor: 1.0
ISSN: 00093122, 15738353
Краткое описание
The aim of this work was to synthesize and study the antituberculosis activity of spirocyclic inhibitors of the MmpL3 protein of M. tu- berculosis containing the 1-oxa-9-azaspiro[5.5]undecane scaffold. Optimization of the initial structure was performed with consideration of the results of molecular docking. The resulting compounds, characterized by the chemical diversity of the peripheral fragment, showed high activity against the antibiotic-sensitive strain H37Rv and some multiresistant strains of M. tuberculosis, exceeding the activity of the comparator drug.
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Komarova K. Y. et al. The synthesis of 1-oxa-9-azaspiro[5.5]undecane derivatives and optimization of antituberculosis activity thereof // Chemistry of Heterocyclic Compounds. 2024. Vol. 60. No. 5-6. pp. 245-250.
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Komarova K. Y., Lukin A. Yu., Vinogradova L. V., Zhuravlev M. E., Dogonadze M. Z., Vinogradova T. I., Gureev M. A., Chudinov M. V., Darin D. V. The synthesis of 1-oxa-9-azaspiro[5.5]undecane derivatives and optimization of antituberculosis activity thereof // Chemistry of Heterocyclic Compounds. 2024. Vol. 60. No. 5-6. pp. 245-250.
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TY - JOUR
DO - 10.1007/s10593-024-03328-w
UR - https://link.springer.com/10.1007/s10593-024-03328-w
TI - The synthesis of 1-oxa-9-azaspiro[5.5]undecane derivatives and optimization of antituberculosis activity thereof
T2 - Chemistry of Heterocyclic Compounds
AU - Komarova, Kristina Yu.
AU - Lukin, Alexey Yu
AU - Vinogradova, Lyubov V.
AU - Zhuravlev, Maxim E.
AU - Dogonadze, Marine Z
AU - Vinogradova, Tatiana I
AU - Gureev, Maxim A
AU - Chudinov, Mikhail V
AU - Darin, Dmitry V
PY - 2024
DA - 2024/06/01
PB - Springer Nature
SP - 245-250
IS - 5-6
VL - 60
SN - 0009-3122
SN - 1573-8353
ER -
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@article{2024_Komarova,
author = {Kristina Yu. Komarova and Alexey Yu Lukin and Lyubov V. Vinogradova and Maxim E. Zhuravlev and Marine Z Dogonadze and Tatiana I Vinogradova and Maxim A Gureev and Mikhail V Chudinov and Dmitry V Darin},
title = {The synthesis of 1-oxa-9-azaspiro[5.5]undecane derivatives and optimization of antituberculosis activity thereof},
journal = {Chemistry of Heterocyclic Compounds},
year = {2024},
volume = {60},
publisher = {Springer Nature},
month = {jun},
url = {https://link.springer.com/10.1007/s10593-024-03328-w},
number = {5-6},
pages = {245--250},
doi = {10.1007/s10593-024-03328-w}
}
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Komarova, Kristina Yu., et al. “The synthesis of 1-oxa-9-azaspiro[5.5]undecane derivatives and optimization of antituberculosis activity thereof.” Chemistry of Heterocyclic Compounds, vol. 60, no. 5-6, Jun. 2024, pp. 245-250. https://link.springer.com/10.1007/s10593-024-03328-w.