N6-methyladenosine (m6A) reader HNRNPA2B1 accelerates the cervical cancer cells aerobic glycolysis
Publication type: Journal Article
Publication date: 2024-10-19
scimago Q3
wos Q2
SJR: 0.644
CiteScore: 5.1
Impact factor: 3.0
ISSN: 0145479X, 15736881
PubMed ID:
39425888
Abstract
N6-methyladenosine (m6A) modification is, a more common epigenetic modification, mainly found in mRNA. More and more researches have shown the important functions of m6A on human cancers. This study seeks to explore the role of hnRNPA2B1 and m6A-dependent mechanism in cervical cancer. Elevated hnRNPA2B1 indicated the poor prognosis of cervical cancer patients. Enforced hnRNPA2B1 reduced the apoptosis, and accelerated the proliferation and migration of cervical cancer cells in vitro. Besides, hnRNPA2B1 promoted the aerobic glycolysis of cervical cancer cells, including the lactate secretion, glucose uptake, ATP production, extracellular acidification rate (ECAR) and oxygen consumption rate (OCR). LDHA was found as the downstream target of hnRNPA2B1 by m6A site. Moreover, hnRNPA2B1 enhanced the mRNA stability of LDHA through m6A-dependent manner. LDHA inhibitor (FX-11) could reverse the effect of hnRNPA2B1. Taken together, the data revealed that hnRNPA2B1 promoted the proliferation, migration and aerobic glycolysis of cervical cancer cells by m6A/LDHA-dependent manner. These findings might bring a new idea for cervical cancer treatment.
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5
Total citations:
5
Citations from 2024:
5
(100%)
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Wen M. et al. N6-methyladenosine (m6A) reader HNRNPA2B1 accelerates the cervical cancer cells aerobic glycolysis // Journal of Bioenergetics and Biomembranes. 2024. Vol. 56. No. 6. pp. 657-668.
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Wen M., Yi N., Mijiti B., Zhao S., Shen G. N6-methyladenosine (m6A) reader HNRNPA2B1 accelerates the cervical cancer cells aerobic glycolysis // Journal of Bioenergetics and Biomembranes. 2024. Vol. 56. No. 6. pp. 657-668.
Cite this
RIS
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TY - JOUR
DO - 10.1007/s10863-024-10042-x
UR - https://link.springer.com/10.1007/s10863-024-10042-x
TI - N6-methyladenosine (m6A) reader HNRNPA2B1 accelerates the cervical cancer cells aerobic glycolysis
T2 - Journal of Bioenergetics and Biomembranes
AU - Wen, Mengke
AU - Yi, Na
AU - Mijiti, Bulabiyamu
AU - Zhao, Shihong
AU - Shen, Guqun
PY - 2024
DA - 2024/10/19
PB - Springer Nature
SP - 657-668
IS - 6
VL - 56
PMID - 39425888
SN - 0145-479X
SN - 1573-6881
ER -
Cite this
BibTex (up to 50 authors)
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@article{2024_Wen,
author = {Mengke Wen and Na Yi and Bulabiyamu Mijiti and Shihong Zhao and Guqun Shen},
title = {N6-methyladenosine (m6A) reader HNRNPA2B1 accelerates the cervical cancer cells aerobic glycolysis},
journal = {Journal of Bioenergetics and Biomembranes},
year = {2024},
volume = {56},
publisher = {Springer Nature},
month = {oct},
url = {https://link.springer.com/10.1007/s10863-024-10042-x},
number = {6},
pages = {657--668},
doi = {10.1007/s10863-024-10042-x}
}
Cite this
MLA
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Wen, Mengke, et al. “N6-methyladenosine (m6A) reader HNRNPA2B1 accelerates the cervical cancer cells aerobic glycolysis.” Journal of Bioenergetics and Biomembranes, vol. 56, no. 6, Oct. 2024, pp. 657-668. https://link.springer.com/10.1007/s10863-024-10042-x.