In Silico Molecular Analysis and Docking of Potent Antimicrobial Peptides Against MurE Enzyme of Methicillin Resistant Staphylococcus Aureus
Abdelmajid Zouhir
1
,
Sonia Jemli
2, 3
,
Rania Omrani
4
,
Amani Kthiri
5
,
Taoufik Jridi
1
,
Khaled Sebei
1
2
Laboratory of Microbial Biotechnology, Enzymatic and Biomolecules (LMBEB), Centre of Biotechnology of Sfax, Sfax, Tunisia
|
Publication type: Journal Article
Publication date: 2021-01-28
scimago Q3
wos Q3
SJR: 0.449
CiteScore: 5.5
Impact factor: 2.4
ISSN: 15733149, 15733904
Drug Discovery
Biochemistry
Molecular Medicine
Analytical Chemistry
Bioengineering
Abstract
During the last decade there has been an alarming increase in the appearance of antibiotic-resistant bacteria. The drug-resistant microorganisms dubbed superbugs are projected to kill 10 million people a year by 2050. The annual frequency of deaths from Methicillin-resistant Staphylococcus aureus (MRSA) is rapidly increasing and surpassing those caused by human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS). Muramyl ligase E (MurE), an enzyme involved in the peptidoglycan biosynthesis of the bacterial cell wall, is a highly druggable target in MRSA. Six anti Methicillin-resistant Staphylococcus Aureus peptides were selected for deep bioinformatic analysis. The six anti-Methicillin-resistant Staphylococcus Aureus peptides were modeled and then docked to MurE ligase and their binding interactions were studied. The findings suggested that the interactions of three antimicrobial peptides (Flowlicidin-2, Ostricacin-2 and Ostricacin-3) with MurE could be essential for their inhibitory activity.
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Total citations:
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Citations from 2024:
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GOST
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Zouhir A. et al. In Silico Molecular Analysis and Docking of Potent Antimicrobial Peptides Against MurE Enzyme of Methicillin Resistant Staphylococcus Aureus // International Journal of Peptide Research and Therapeutics. 2021. Vol. 27. No. 2. pp. 1253-1263.
GOST all authors (up to 50)
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Zouhir A., Jemli S., Omrani R., Kthiri A., Jridi T., Sebei K. In Silico Molecular Analysis and Docking of Potent Antimicrobial Peptides Against MurE Enzyme of Methicillin Resistant Staphylococcus Aureus // International Journal of Peptide Research and Therapeutics. 2021. Vol. 27. No. 2. pp. 1253-1263.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1007/s10989-021-10165-4
UR - https://doi.org/10.1007/s10989-021-10165-4
TI - In Silico Molecular Analysis and Docking of Potent Antimicrobial Peptides Against MurE Enzyme of Methicillin Resistant Staphylococcus Aureus
T2 - International Journal of Peptide Research and Therapeutics
AU - Zouhir, Abdelmajid
AU - Jemli, Sonia
AU - Omrani, Rania
AU - Kthiri, Amani
AU - Jridi, Taoufik
AU - Sebei, Khaled
PY - 2021
DA - 2021/01/28
PB - Springer Nature
SP - 1253-1263
IS - 2
VL - 27
SN - 1573-3149
SN - 1573-3904
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2021_Zouhir,
author = {Abdelmajid Zouhir and Sonia Jemli and Rania Omrani and Amani Kthiri and Taoufik Jridi and Khaled Sebei},
title = {In Silico Molecular Analysis and Docking of Potent Antimicrobial Peptides Against MurE Enzyme of Methicillin Resistant Staphylococcus Aureus},
journal = {International Journal of Peptide Research and Therapeutics},
year = {2021},
volume = {27},
publisher = {Springer Nature},
month = {jan},
url = {https://doi.org/10.1007/s10989-021-10165-4},
number = {2},
pages = {1253--1263},
doi = {10.1007/s10989-021-10165-4}
}
Cite this
MLA
Copy
Zouhir, Abdelmajid, et al. “In Silico Molecular Analysis and Docking of Potent Antimicrobial Peptides Against MurE Enzyme of Methicillin Resistant Staphylococcus Aureus.” International Journal of Peptide Research and Therapeutics, vol. 27, no. 2, Jan. 2021, pp. 1253-1263. https://doi.org/10.1007/s10989-021-10165-4.
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