The role of the ER stress sensor IRE1 in cardiovascular diseases

Publication type: Journal Article
Publication date: 2024-05-08
Springer Nature
scimago Q1
wos Q2
SJR: 1.033
CiteScore: 9.0
Impact factor: 3.7
ISSN: 03008177, 15734919
Abstract
Despite enormous advances in the treatment of cardiovascular diseases, including I/R injury and heart failure, heart diseases remain a leading cause of mortality worldwide. Inositol-requiring enzyme 1 (IRE1) is an evolutionarily conserved sensor endoplasmic reticulum (ER) transmembrane protein that senses ER stress. It manages ER stress induced by the accumulation of unfolded/misfolded proteins via the unfolded protein response (UPR). However, if the stress still persists, the UPR pathways are activated and induce cell death. Emerging evidence shows that, beyond the UPR, IRE1 participates in the progression of cardiovascular diseases by regulating inflammation levels, immunity, and lipid metabolism. Here, we summarize the recent findings and discuss the potential therapeutic effects of IRE1 in the treatment of cardiovascular diseases.
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GOST Copy
Zhou L. et al. The role of the ER stress sensor IRE1 in cardiovascular diseases // Molecular and Cellular Biochemistry. 2024.
GOST all authors (up to 50) Copy
Zhou L., Zhu X., Lei S., Wang Y., Xia Z. The role of the ER stress sensor IRE1 in cardiovascular diseases // Molecular and Cellular Biochemistry. 2024.
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RIS Copy
TY - JOUR
DO - 10.1007/s11010-024-05014-z
UR - https://link.springer.com/10.1007/s11010-024-05014-z
TI - The role of the ER stress sensor IRE1 in cardiovascular diseases
T2 - Molecular and Cellular Biochemistry
AU - Zhou, Lu
AU - Zhu, Xizi
AU - Lei, Shaoqing
AU - Wang, Yafeng
AU - Xia, Zhongyuan
PY - 2024
DA - 2024/05/08
PB - Springer Nature
PMID - 38717685
SN - 0300-8177
SN - 1573-4919
ER -
BibTex
Cite this
BibTex (up to 50 authors) Copy
@article{2024_Zhou,
author = {Lu Zhou and Xizi Zhu and Shaoqing Lei and Yafeng Wang and Zhongyuan Xia},
title = {The role of the ER stress sensor IRE1 in cardiovascular diseases},
journal = {Molecular and Cellular Biochemistry},
year = {2024},
publisher = {Springer Nature},
month = {may},
url = {https://link.springer.com/10.1007/s11010-024-05014-z},
doi = {10.1007/s11010-024-05014-z}
}