Anti-TMV activity based flavonol derivatives containing piperazine sulfonyl: Design, synthesis and mechanism study

Тип публикации: Journal Article
Дата публикации: 2025-01-22
Springer Nature
scimago Q2
wos Q2
БС1
SJR: 0.646
CiteScore: 8.5
Impact factor: 3.8
ISSN: 13811991, 1573501X
Краткое описание
A series of flavonoid derivatives containing piperazine sulfonate were designed and synthesized. The results of antiviral experiments in vivo showed that some target compounds had good inhibitory effect on tobacco mosaic virus (TMV). The EC50 values of S15 and S19 curative activity were 174.5 and 110.4 μg/mL, respectively, which were better than 253.7 μg/mL of Ningnanmycin (NNM). The EC50 values of S4 and S19 protection activity were 140.3 and 116.1 μg/mL, respectively, better than that of NNM (247.1 μg/mL). Microscale thermophoresis (MST) and molecular docking experiments showed that S19 had a good molecular binding force with TMV. Transmission electron microscopy (TEM) results show that S19 can fracture TMV particles and affect self-assembly. S19 treatment had almost no effect on the growth of seeds and seedlings, and can change the content of chlorophyll malondialdehyde (MDA) and superoxide dismutase (SOD) in tobacco to a certain extent, and improve the disease resistance of tobacco.
Найдено 
Для доступа к списку цитирований публикации необходимо авторизоваться.

Топ-30

Журналы

1
Pesticide Biochemistry and Physiology
Pesticide Biochemistry and Physiology, 1, 33.33%
Pesticide Biochemistry and Physiology
1 публикация, 33.33%
Molecular Diversity
Molecular Diversity, 1, 33.33%
Molecular Diversity
1 публикация, 33.33%
Pest Management Science
Pest Management Science, 1, 33.33%
Pest Management Science
1 публикация, 33.33%
1

Издатели

1
Elsevier
Elsevier, 1, 33.33%
Elsevier
1 публикация, 33.33%
Springer Nature
Springer Nature, 1, 33.33%
Springer Nature
1 публикация, 33.33%
Wiley
Wiley, 1, 33.33%
Wiley
1 публикация, 33.33%
1
  • Мы не учитываем публикации, у которых нет DOI.
  • Статистика публикаций обновляется еженедельно.

Вы ученый?

Создайте профиль, чтобы получать персональные рекомендации коллег, конференций и новых статей.
Метрики
3
Поделиться
Цитировать
ГОСТ |
Цитировать
ГОСТ Скопировать
Sun Z. et al. Anti-TMV activity based flavonol derivatives containing piperazine sulfonyl: Design, synthesis and mechanism study // Molecular Diversity. 2025.
ГОСТ со всеми авторами (до 50) Скопировать
Sun Z., Zeng W., Qiu Y., Hu Y., Zhou Q., Hu C., Wang Y., Xue W. Anti-TMV activity based flavonol derivatives containing piperazine sulfonyl: Design, synthesis and mechanism study // Molecular Diversity. 2025.
RIS |
Цитировать
RIS Скопировать
TY - JOUR
DO - 10.1007/s11030-025-11109-6
UR - https://link.springer.com/10.1007/s11030-025-11109-6
TI - Anti-TMV activity based flavonol derivatives containing piperazine sulfonyl: Design, synthesis and mechanism study
T2 - Molecular Diversity
AU - Sun, Zhiling
AU - Zeng, Wei
AU - Qiu, Yujiao
AU - Hu, Yuzhi
AU - Zhou, Qing
AU - Hu, Chunmei
AU - Wang, Yuhong
AU - Xue, Wei
PY - 2025
DA - 2025/01/22
PB - Springer Nature
SN - 1381-1991
SN - 1573-501X
ER -
BibTex
Цитировать
BibTex (до 50 авторов) Скопировать
@article{2025_Sun,
author = {Zhiling Sun and Wei Zeng and Yujiao Qiu and Yuzhi Hu and Qing Zhou and Chunmei Hu and Yuhong Wang and Wei Xue},
title = {Anti-TMV activity based flavonol derivatives containing piperazine sulfonyl: Design, synthesis and mechanism study},
journal = {Molecular Diversity},
year = {2025},
publisher = {Springer Nature},
month = {jan},
url = {https://link.springer.com/10.1007/s11030-025-11109-6},
doi = {10.1007/s11030-025-11109-6}
}