MHP-133, a Drug with Multiple CNS Targets: Potential for Neuroprotection and Enhanced Cognition
Jerry J. Buccafusco
1, 2
,
James C. POWERS
3
,
Maria A. Hernandez
3, 4
,
Mark A. Prendergast
5
,
Alvin V. Terry
1
,
Ramamohana R. Jonnala
1
1
Alzheimer’s Research Center, Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, USA
|
2
Medical Research Service, Veterans Administration Medical Center, Augusta, USA
|
Publication type: Journal Article
Publication date: 2007-04-03
scimago Q1
wos Q2
SJR: 1.103
CiteScore: 8.1
Impact factor: 3.8
ISSN: 03643190, 15736903
PubMed ID:
17404838
Biochemistry
General Medicine
Cellular and Molecular Neuroscience
Abstract
MHP-133 is one of a novel series of compounds designed to target multiple brain substrates expected to have synergistic actions in the treatment of cognitive and neurodegenerative disorders such as Alzheimer’s disease. The strategy was to develop compounds with multiple targets relevant for enhancing cognition and memory, but avoiding the serious side effects attributed to high potency cholinergic agonists. MHP-133 was shown to interact with subtypes of cholinergic, serotonergic, and imidazoline receptors and to weakly inhibit acetylcholinesterase activity. In vitro, the drug enhanced nerve growth factor (TrkA) receptor expression; it prevented excitotoxicity in a hippocampal slice preparation; and increased the secretion of soluble (non-toxic) amyloid precursor protein. MHP-133 also enhanced cognitive performance by rats and by non-human primate in tasks designed to assess working memory. The results of this study are consistent with the potential use of MHP-133 in the treatment of neurodegenerative disorders such as Alzheimer’s disease.
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Buccafusco J. J. et al. MHP-133, a Drug with Multiple CNS Targets: Potential for Neuroprotection and Enhanced Cognition // Neurochemical Research. 2007. Vol. 32. No. 7. pp. 1224-1237.
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Buccafusco J. J., POWERS J. C., Hernandez M. A., Prendergast M. A., Terry A. V., Jonnala R. R. MHP-133, a Drug with Multiple CNS Targets: Potential for Neuroprotection and Enhanced Cognition // Neurochemical Research. 2007. Vol. 32. No. 7. pp. 1224-1237.
Cite this
RIS
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TY - JOUR
DO - 10.1007/s11064-007-9294-0
UR - https://doi.org/10.1007/s11064-007-9294-0
TI - MHP-133, a Drug with Multiple CNS Targets: Potential for Neuroprotection and Enhanced Cognition
T2 - Neurochemical Research
AU - Buccafusco, Jerry J.
AU - POWERS, James C.
AU - Hernandez, Maria A.
AU - Prendergast, Mark A.
AU - Terry, Alvin V.
AU - Jonnala, Ramamohana R.
PY - 2007
DA - 2007/04/03
PB - Springer Nature
SP - 1224-1237
IS - 7
VL - 32
PMID - 17404838
SN - 0364-3190
SN - 1573-6903
ER -
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BibTex (up to 50 authors)
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@article{2007_Buccafusco,
author = {Jerry J. Buccafusco and James C. POWERS and Maria A. Hernandez and Mark A. Prendergast and Alvin V. Terry and Ramamohana R. Jonnala},
title = {MHP-133, a Drug with Multiple CNS Targets: Potential for Neuroprotection and Enhanced Cognition},
journal = {Neurochemical Research},
year = {2007},
volume = {32},
publisher = {Springer Nature},
month = {apr},
url = {https://doi.org/10.1007/s11064-007-9294-0},
number = {7},
pages = {1224--1237},
doi = {10.1007/s11064-007-9294-0}
}
Cite this
MLA
Copy
Buccafusco, Jerry J., et al. “MHP-133, a Drug with Multiple CNS Targets: Potential for Neuroprotection and Enhanced Cognition.” Neurochemical Research, vol. 32, no. 7, Apr. 2007, pp. 1224-1237. https://doi.org/10.1007/s11064-007-9294-0.