HPLC/MS Determination of Enalapril and Enalaprilat in the Blood Plasma
V V Pisarev
1
,
N E Moskaleva
1
,
Yu B Zverkov
1
,
L B Smirnova
1
,
V G Belolipetskaya
2
,
Ya V Sukhanov
2
1
State Scientific Center for Antibiotics, Moscow, Russia
|
2
State Research Center for Preventive Medicine, Ministry of Public Health of the Russian Federation, Moscow, Russia
|
Publication type: Journal Article
Publication date: 2005-02-01
scimago Q4
wos Q4
SJR: 0.219
CiteScore: 1.4
Impact factor: 1.0
ISSN: 0091150X, 15739031
Drug Discovery
Pharmacology
Abstract
A reproducible and sensitive analytical procedure has been developed for the quantitative determination of enalapril and enalaprilat in the blood plasma by high-performance liquid chromatography with mass-spectrometric detection (HPLC/MS). For increasing the sensitivity and reproducibility of analyses, the samples were treated with diazomethane in order to obtain methyl esters of the analyzed compounds. The quantitative determination was carried out using the internal standard method; the internal standard was captopril. The detection was performed in the positive ion mode for ions with m/z = 377 (enalaprilat methyl ester), 391 (enalapril methyl ester), and 267 (captopril methyl ester). Enalapril, enalaprilat, and captopril were isolated from the blood plasma and purified by means of solid-phase extraction. The calibration plot is linear in the concentration range from 0.5 to 200 ng/ml. The detection limits for both enalaprilat and enalapril in the blood plasma are 0.1 ng/ml.
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Metrics
11
Total citations:
11
Citations from 2024:
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(9.09%)
The most citing journal
Citations in journal:
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MLA
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GOST
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Pisarev V. V. et al. HPLC/MS Determination of Enalapril and Enalaprilat in the Blood Plasma // Pharmaceutical Chemistry Journal. 2005. Vol. 39. No. 2. pp. 104-107.
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Pisarev V. V., Moskaleva N. E., Zverkov Yu. B., Smirnova L. B., Belolipetskaya V. G., Sukhanov Ya. V. HPLC/MS Determination of Enalapril and Enalaprilat in the Blood Plasma // Pharmaceutical Chemistry Journal. 2005. Vol. 39. No. 2. pp. 104-107.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1007/s11094-005-0094-z
UR - https://doi.org/10.1007/s11094-005-0094-z
TI - HPLC/MS Determination of Enalapril and Enalaprilat in the Blood Plasma
T2 - Pharmaceutical Chemistry Journal
AU - Pisarev, V V
AU - Moskaleva, N E
AU - Zverkov, Yu B
AU - Smirnova, L B
AU - Belolipetskaya, V G
AU - Sukhanov, Ya V
PY - 2005
DA - 2005/02/01
PB - Springer Nature
SP - 104-107
IS - 2
VL - 39
SN - 0091-150X
SN - 1573-9031
ER -
Cite this
BibTex (up to 50 authors)
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@article{2005_Pisarev,
author = {V V Pisarev and N E Moskaleva and Yu B Zverkov and L B Smirnova and V G Belolipetskaya and Ya V Sukhanov},
title = {HPLC/MS Determination of Enalapril and Enalaprilat in the Blood Plasma},
journal = {Pharmaceutical Chemistry Journal},
year = {2005},
volume = {39},
publisher = {Springer Nature},
month = {feb},
url = {https://doi.org/10.1007/s11094-005-0094-z},
number = {2},
pages = {104--107},
doi = {10.1007/s11094-005-0094-z}
}
Cite this
MLA
Copy
Pisarev, V. V., et al. “HPLC/MS Determination of Enalapril and Enalaprilat in the Blood Plasma.” Pharmaceutical Chemistry Journal, vol. 39, no. 2, Feb. 2005, pp. 104-107. https://doi.org/10.1007/s11094-005-0094-z.
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