Cytotoxic, Antibacterial, and Algaecidal Activity of Copper(II) Complexes of Arylmethylene-Bis(4-Hydroxy-6-Methyl-2H-Pyran-2-Ones)

The in vitro biological properties of previously obtained copper(II) complexes of arylmethylene-bis(4-hydroxy-6-methyl-2H-pyran-2-ones) were studied. The cytotoxic properties of all complexes against human cervical cancer cell line HeLa were determined. The antibacterial properties of the copper(II) complexes against Gram-negative and Gram-positive bacteria were determined. Di[3,3′-(phenylmethylene)-bis(4-hydroxy-6-methyl-2H-pyran-2-one)]copper(II) and di{3,3′-[(3-nitrophenyl)methylene]-bis(4-hydroxy-6-methyl-2H-pyran-2-one)}copper(II) tetrahydrates were characterized by pronounced algaecidal activity in vitro against Dunaliella salina. The prospects of searching for pharmacologically active substances of interest as potential drugs in series of copper(II) complexes of arylmethylene-bis(4-hydroxy-6-methyl-2H-pyran-2-ones) are shown.