Springer Nature
Pharmaceutical Chemistry Journal
,  volume 58 ,  issue 7 ,  pages 1054-1056

Analgesic Activity of Methyl-6-Aryl-5-Aroyl-4-Methoxy-2-Oxo(Thioxo)-Hexahydropyrimidine-4-Carboxylates

Publication type: Journal Article
Publication date: 2024-10-01
Springer Nature
scimago Q4
wos Q4
SJR: 0.219
CiteScore: 1.4
Impact factor: 1.0
ISSN: 0091150X, 15739031
Abstract
The analgesic activity of nine new compounds of the methyl-6-aryl-5-aroyl-4-methoxy-2-oxo-(thioxo)hexahydropyrimidine-4-carboxylate series was studied using the acetic writhing method. Six compounds were found not to exhibit acute toxicity and to have analgesic activity greater than that of metamizole sodium. The actions of these compounds in experimental animals decreased the number of acetic writhings by 58–85%. This class of compounds has promise for further searches for biologically active compounds with analgesic activity.
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Gorgopina E. V. et al. Analgesic Activity of Methyl-6-Aryl-5-Aroyl-4-Methoxy-2-Oxo(Thioxo)-Hexahydropyrimidine-4-Carboxylates // Pharmaceutical Chemistry Journal. 2024. Vol. 58. No. 7. pp. 1054-1056.
GOST all authors (up to 50) Copy
Gorgopina E. V., Zamaraeva T. M., Rudakova I. P., Gein V. L. Analgesic Activity of Methyl-6-Aryl-5-Aroyl-4-Methoxy-2-Oxo(Thioxo)-Hexahydropyrimidine-4-Carboxylates // Pharmaceutical Chemistry Journal. 2024. Vol. 58. No. 7. pp. 1054-1056.
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TY - JOUR
DO - 10.1007/s11094-024-03243-6
UR - https://link.springer.com/10.1007/s11094-024-03243-6
TI - Analgesic Activity of Methyl-6-Aryl-5-Aroyl-4-Methoxy-2-Oxo(Thioxo)-Hexahydropyrimidine-4-Carboxylates
T2 - Pharmaceutical Chemistry Journal
AU - Gorgopina, E V
AU - Zamaraeva, T M
AU - Rudakova, I. P.
AU - Gein, V L
PY - 2024
DA - 2024/10/01
PB - Springer Nature
SP - 1054-1056
IS - 7
VL - 58
SN - 0091-150X
SN - 1573-9031
ER -
BibTex |
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BibTex (up to 50 authors) Copy
@article{2024_Gorgopina,
author = {E V Gorgopina and T M Zamaraeva and I. P. Rudakova and V L Gein},
title = {Analgesic Activity of Methyl-6-Aryl-5-Aroyl-4-Methoxy-2-Oxo(Thioxo)-Hexahydropyrimidine-4-Carboxylates},
journal = {Pharmaceutical Chemistry Journal},
year = {2024},
volume = {58},
publisher = {Springer Nature},
month = {oct},
url = {https://link.springer.com/10.1007/s11094-024-03243-6},
number = {7},
pages = {1054--1056},
doi = {10.1007/s11094-024-03243-6}
}
MLA
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Gorgopina, E. V., et al. “Analgesic Activity of Methyl-6-Aryl-5-Aroyl-4-Methoxy-2-Oxo(Thioxo)-Hexahydropyrimidine-4-Carboxylates.” Pharmaceutical Chemistry Journal, vol. 58, no. 7, Oct. 2024, pp. 1054-1056. https://link.springer.com/10.1007/s11094-024-03243-6.