Efficient synthesis of decahydroacridine-1,8-diones and polyhydroquinolines using the step-wise method
Publication type: Journal Article
Publication date: 2022-01-04
scimago Q2
wos Q2
SJR: 0.528
CiteScore: 5.7
Impact factor: 3.5
ISSN: 09226168, 15685675
General Chemistry
Abstract
Various symmetrical and unsymmetrical decahydroacridine-1,8-dione and polyhydroquinoline derivatives were synthesized via two-step cyclocondensation reactions. The advantages of this step-wise addition of reactants in comparison with other one-pot reactions are avoiding the formation of 2 or 3 undesired by-products, therefore allowing cleaner work up of reaction. The important factor of this effective cyclocondensation method is that the prepared β-enaminone component was added dropwise to the solution, in which the Knoevenagel condensation product is slowly being formed by reaction of aldehyde molecule and 1,3-dicarbonyl compounds. The results of the proposed step-wise method are compared and discussed with those obtained in the one-pot reactions.
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Hosseininasab F. S., Memarian H. R. Efficient synthesis of decahydroacridine-1,8-diones and polyhydroquinolines using the step-wise method // Research on Chemical Intermediates. 2022. Vol. 48. No. 4. pp. 1515-1540.
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Hosseininasab F. S., Memarian H. R. Efficient synthesis of decahydroacridine-1,8-diones and polyhydroquinolines using the step-wise method // Research on Chemical Intermediates. 2022. Vol. 48. No. 4. pp. 1515-1540.
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RIS
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TY - JOUR
DO - 10.1007/s11164-021-04643-z
UR - https://doi.org/10.1007/s11164-021-04643-z
TI - Efficient synthesis of decahydroacridine-1,8-diones and polyhydroquinolines using the step-wise method
T2 - Research on Chemical Intermediates
AU - Hosseininasab, Fatemeh Sadat
AU - Memarian, Hamid Reza
PY - 2022
DA - 2022/01/04
PB - Springer Nature
SP - 1515-1540
IS - 4
VL - 48
SN - 0922-6168
SN - 1568-5675
ER -
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BibTex (up to 50 authors)
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@article{2022_Hosseininasab,
author = {Fatemeh Sadat Hosseininasab and Hamid Reza Memarian},
title = {Efficient synthesis of decahydroacridine-1,8-diones and polyhydroquinolines using the step-wise method},
journal = {Research on Chemical Intermediates},
year = {2022},
volume = {48},
publisher = {Springer Nature},
month = {jan},
url = {https://doi.org/10.1007/s11164-021-04643-z},
number = {4},
pages = {1515--1540},
doi = {10.1007/s11164-021-04643-z}
}
Cite this
MLA
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Hosseininasab, Fatemeh Sadat, and Hamid Reza Memarian. “Efficient synthesis of decahydroacridine-1,8-diones and polyhydroquinolines using the step-wise method.” Research on Chemical Intermediates, vol. 48, no. 4, Jan. 2022, pp. 1515-1540. https://doi.org/10.1007/s11164-021-04643-z.